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Document pyrano[2,3-b] pyridines MDL 20,610, MDL 20,646, and MDL 20,957. Antimicrob Agents Chemother 1986; 30:516–518. Page 523 68. Kelly JL, Linn JA, Selway JWT. Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines. J Med Chem 1990; 33:1360–1363. 69. Alarcon B, Zerial A, Dupiol C, Carrasco L. Antirhinovirus compound 44081 R. P. inhibits virus uncoating. Antimicrob Agents Chemother 1986; 30(1):31–34. 70. Filman DJ, Syed R, Chow M, Mcadam AJ, Minor PD, Hogle JM. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO 1989; 8(5):1567–1579. 71. Yeates TO, Jacobson DH, Martin A, et al. Three-dimensional structure of a mouse adapted type2/type1 chimera. EMBO 1991; 10:2331–2341. 72. Smyth M, Fry E, Stuart D, Lyons C, Hoey E, Martin SJ. Preliminary crystallographic analysis of bovine enterovirus. J Mol Biol 1993; 231(3):930–932. 73. Grant RA, Hiremath CN, Filman DJ, Syed R, Andries K, Hogle JM. Structures of poliovirus complexes with anti-viral drugs: Implications for viral stability and drug design. Curr Biol 1994; 4:784–797. 74. Eriksson AE, Baase WA, Wozniak JA, Matthews BA. A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene. Nature 1992; 355:371–373. 75. Sattar SA, Jacobsen H, Springthorpe VS, Cusack TM, Rubino JR. Chemical disinfection to interrupt transfer of rhinovirus type-14 from environmental surfaces to hands. Appl Environ Microbiol 1993; 59(5):1579–1585. 76. Hendley JO, Wenzel RP, Gwaltney JMJ. Transmission of rhinovirus colds by self-inoculation. N Engl J Med 1973; 288:1361–1364. 77. Jaeger EP, Pevear DC, Felock PJ, Russo GR, Treasurywala AM. Genetic algorithm based method to design a primary screen for antirhinovirus agents. Am Chem Soc Symp Ser 1995; 589:139–155. 78. Fox MP, McKinlay MA, Diana GD, Dutko FJ. The binding affinities of structurally related human rhinovirus capsid-binding compounds correlate with antiviral activity. Antimicrob Agents Chemother 1991; 35:1040–1047. 79. Bibler-Muckelbauer JK, Kremer MJ, Rossmann MG, et al. Human rhinovirus 14 complexed with fragments of active antiviral compounds. Virology 1994; 201:360–369. 80. Diana GD, Cutcliffe D, Oglesby RC, et al. Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornaviruses. J Med Chem 1989; 32:450–455. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_523.html (1 of 2) [4/9/2004 12:46:42 AM]
Document 81. Diana GD, McKinlay MA, Otto MJ, Akullian V, Ogelsby C. [[(4,5-Dihydro-2oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating. J Med Chem 1985; 28:1906–1910. 82. Diana GD, Oglesby RC, Akullian V, et al. Structure-activity studies of 5-[[4-(4,5-Dihydro-2oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating. J Med Chem 1987; 30:383–388. 83. Diana GD, Otto MJ, Treasurywala AM, et al. Enantiomeric effects of homologues of disoxaril in the inhibitory activity against human rhinovirus 14. J Med Chem 1988; 31:540–544. 84. Horsnell C, Gama RE, Hughes PJ, Stanway G. Molecular relationships between 21 human rhinovirus serotypes. J Gen Virol 1995; 76:2549–2555. 85. Diana GD, Kowalczyk P, Treasurywala AM, Oglesby RC, Pevear DC, Dutko FJ. CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14. J Med Chem 1992; 35:1002–1008. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_523.html (2 of 2) [4/9/2004 12:46:42 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document reverse transcriptase inhi
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Figure 6 Rat and human B2
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document IV. Drug Design Progressio
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Document Cyclotheonamide A (CtA), a
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Document D ddI, 152 tumour necrosis
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Document [Protease targets] serinyl
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