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Document Page 316 12. Nankervis R, Lues I, Brown L. Calcium sensitization as a positive inotropic mechanism in diseased rat and human heart. J Cardiovasc Pharmacol 1994; 24:612–617. 13. Doggrell S, Hoey A, Brown L. Ion channel modulators as potential positive inotropic compounds for treatment of heart failure. Clin Exp Pharmacol Physiol 1988; 21:833–843. 14. Briggs GM, Gwathmey JK. Role of the sodium channel in the development of force in myocardium. In: Gwathmey JK, Briggs GM, Allen PD, eds. Heart failure. Basic science and clinical aspects. New York: Marcel Dekker, 1993:597–612. 15. Hoey A, Amos GJ, Wettwer E, Ravens U. Differential effects of BDF 9148 and DPI 201-106 on action potential and contractility in rat and guinea-pig myocardium. J Cardiovasc Pharmacol 1994; 23:907–915. 16. Schwinger RHG, Böhm M, Mittmann C, La Rosee K, Erdmann E. Evidence for a sustained effectiveness of sodium-channel activators in failing human myocardium. J Mol Cell Cardiol 1991; 23:461–471. 17. Hoey A, Nankervis R, Brown L. Positive inotropic responses of the sodium channel modulator BDF 9148 in diseased rat myocardium. Clin Exp Pharmacol Physiol 1995; 22:418–422. 18. Norton TR. Cardiotonic polypeptides from Anthopleura xanthogrammica (Brandt) and A. elegantissima (Brandt). Fed Proc 1981; 40:21–25. 19. Beress L. Biologically active compounds from coelenterates. Pure Appl Chem 1982; 54:1981–1994. 20. Tanaka M, Haniu M, Yasunobu KT, Norton TR. Amino acid sequence of the Anthopleura xanthogrammica heart stimulant anthopleurin-A. Biochemistry 1977; 16:204–208. 21. Blair RW, Peterson DF, Bishop VS. The effects of anthopleurin-A on cardiac dynamics in conscious dogs. J Pharmacol Exp Ther 1978; 207:271–276. 22. Kodama I, Toyama J, Shibata S, Norton TR. Electrical and mechanical effects of anthopleurin-A, a polypeptide from a sea anemone, on isolated rabbit ventricular muscle under conditions of hypoxia and glucose free medium. J. Cardiovasc Pharmacol 1981; 3:75–86. 23. Gross GJ, Warltier DC, Hardman HF, Shibata S. Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis. Eur J Pharmacol 1985; 110:271–276. 24. Norton RS. <strong>Structure</strong> and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon 1991; 29:1051–1084. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_316.html (1 of 2) [4/5/2004 5:24:11 PM]
Document 25. Malpezzi ELA, De Freitas JC, Muramoto K, Kamiya H. Characterization of peptides in sea anemone venom collected <strong>by</strong> a novel procedure. Toxicon 1993; 31:853–864. 26. Loret EP, Menendez Soto del Valle R, Mansuelle P, Sampieri F, Rochat H. Positively charged amino acid residues located similarly in sea anemone and scorpion toxins. J Biol Chem 1994; 269:16785–16788. 27. Kem WR. Sea anemone toxins: structure and action. In: Hessinger D, Lenhoff H, eds. The Biology of Nematocysts. New York: Academic Press, 1988:375–405. 28. Alsen C. Biological significance of peptides from Anemonia sulcata. Fed Proc 1983;42:101–108. 29. Renaud J-F, Fosset M, Schweitz H, Lazdunski M. The interaction of polypeptide neurotoxins with tetrodotoxin-resistant Na + channels in mammalian cardiac cells. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_316.html (2 of 2) [4/5/2004 5:24:11 PM]
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Structure-based Drug Design 14 Stru
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Document 106. Cirino NM, Cameron CE
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Document 163. Lacey SF, Larder BA.
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Document We determined the structur
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Document Figure 3 Previously known
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Document IV. Drug Design Progressio
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Page 363 and 364: Document 12 Polypeptide Modulators
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Page 421 and 422: Document Page 343 14 Structural Asp
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Document All effects of the IL-1 fa
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document Page 476 nM, respectively.
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Acknowledgments Page 620 I
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document overview, 103-104, 108-109
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Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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