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Document 3. Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE. Threedimensional structure of recombinant human interferon-g. Science 1991; 252:698–702. Page 454 4. Samudzi CT, Burton LE, Rubin JR. Crystal structure of recombinant rabbit interferon-gamma at 2.7 A resolution. J Biol Chem 1991; 266:21791–21797. 5. Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zavodny PJ, Narula SK. Crystal structure of a complex between interferon-g and its soluble high-affinity receptor. Nature 1995; 376:230–235. 6. Grzesiek S, Dobeli H, Gentz R, Garotta G, Labhardt AM, Bax A. 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma. Biochemistry 1992; 31 (35):8180–90. 7. Sakai TT, Jablonski MJ, DeMuth PA, Krishna NR, Jarpe MA, Johnson HM. Proton NMR sequence specific assignments and secondary structure of a receptor binding domain of mouse γ-interferon. Biochemistry 1993; 32:5650. 8. Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP. A homology model of human interferon alpha-2. Proteins 1993; 17(1):62–74. 9. Seto MH, Harkins RN, Adler M, Whitlow M, Church WB, Croze E. Homology model of human interferon-alpha-8 and its receptor complex. Protein Science 1995; 4:655–70. 10. Jarpe MA, Johnson HM, Bazer FW, Ott TL, Curto EV, Rama Krishna N, Pontzer CH. Predicted structural motif of IFN-τ. Protein Engineering 1994; 7:863–867. 11. Bazer FW. Mediators of maternal recognition of pregnancy in mammals. Proc Soc Exp Biol Med 1992; 199:373–384. 12. Imakawa K, Anthony RV, Kazemi M, Marotti KR, Polites HG, Roberts RM. Interferon-like sequence of ovine trophoblast protein secreted <strong>by</strong> embryonic trophectoderm. Nature 1987; 330:377–379. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_454.html (1 of 2) [4/9/2004 12:12:10 AM]
Document 13. Stewart HJ, McCann SHE, Barker PJ, Lee KE, Lamming GE, Flint APF. Interferon sequence homology and receptor binding activity of ovine trophoblast antileuteolytic protein. J Endocrinol 1987; 115:R13–R15. 14. Pontzer CH, Ott TL, Bazer FW, Johnson HM. <strong>Structure</strong>/function studies with interferon tau: Evidence for multiple active sites. J Interferon Res 1994; 14:133–141. 15. Fish EN, Banerjee K, Stebbing N. The role of three domains in the biological activity of human interferon-α. J Interferon Res 1989; 9:97–114. 16. Novick D, Cohen B, Rubinstein M. The human interferon α/β receptor: characterization and molecular cloning. Cell 1994; 77:391–400. 17. Pontzer CH, Yamamoto JK, Bazer FW, Ott TL, Johnson HM. Potent anti-feline immunodificiency virus and anti-human immunodeficiency virus effect of interferon tau. J Immunol 1995; (in press). 18. Pontzer CP, Bazer FW, Johnson HM. Antiproliferative activity of a pregnancy recognition hormone, ovine trophoblast protein-1. Cancer Res 1991; 51:5304–5307. 19. Pestka S, Langer JA, Zoon KC, Samuel CE. Interferons and their actions. Annu Rev Biochem 1987; 56:727–777. 20. Barasoain I, Portolès A, Aramburu JF, Rojo JM. Antibodies against a peptide representative of a conserved region of human IFN-α. Differential effects on the antiviral and antiproliferative effects of IFN. J Immunol 1989; 143:507–512. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_454.html (2 of 2) [4/9/2004 12:12:10 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document 4 Bradykinin Receptor Anta
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Document We determined the structur
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Document Figure 3 Previously known
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Page 533 and 534: Document 39. Saurat JH, Schfferli J
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Page 541 and 542: Document 17 Structure and Functiona
Page 543 and 544: Document Table 1 Approval Indicatio
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Page 547 and 548: Document II. Type IFNs A great deal
Page 549 and 550: Document Page 441 sequence of the m
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Page 553 and 554: Document Figure 4 Stereo view of IF
Page 555 and 556: Document Figure 5 Velcro-key model
Page 557 and 558: Document Figure 6 Proposed receptor
Page 559 and 560: Document Page 451 with the cytoplas
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Page 579 and 580: Document B. Protein Structure Page
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Page 583 and 584: Document Page 471 molecules in the
Page 585 and 586: Document hydroxy, and 6 Neu5Ac2en -
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Page 589 and 590: Document Page 476 nM, respectively.
Page 591 and 592: Document Page 478 lished—was asso
Page 593 and 594: Document VI. Conclusion Page 480 It
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document [Protease targets] serinyl
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