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Document 86. De Clercq E. Antiviral therapy of human immunodeficiency virus infections. Clin Microbiol Rev 1995; 8:200–239. 87. Champoux JJ. Roles of ribonuclease H in reverse transcription. In: Skalka AM, Goff SP, eds. Reverse Transcriptase. Plainview, New York: Cold Spring Harbor Laboratory Press, 1993:103–117. 88. Telesnitsky A, Goff SP. Strong-stop strand transfer during reverse transcription. In: Skalka AM, Goff SP eds. Reverse Transcriptase. Plainview, New York: Cold Spring Harbor Laboratory Press, 1993:49–83. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_76.html (2 of 2) [4/5/2004 4:53:14 PM]
Document 89. Hughes SH, Arnold E, Hostomsky Z. RNase H of retroviral reverse transcriptases. Plainview, New York: Cold Spring Harbor Laboratory Press, 1996; in press. 90. Schatz O, Mous J, Le Grice SFJ. HIV-1 RT-associated ribonuclease H displays both endonuclease and 3' 5' exonuclease activity. EMBO J 1990; 9:1171–1176. 91. Tanese N, Goff SP. Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities. Proc Natl Acad Sci USA 1988; 85:1777–1781. 92. Tanese NT, Telesnitsky A, Goff SP. Abortive reverse transcription <strong>by</strong> mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function. J Virol 1991; 65:4387–4397. 93. Tisdale M, Schulze T, Larder BA, Moelling K. Mutations within the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase abolish virus infectivity. J Gen Virol 1991; 72:59–66. 94. Davies JF, Hostomska Z, Hostomsky Z, Jordan SR, Matthews DA. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science 1991; 252:88–95. 95. Chattopadhyay D, Finzel BC, Munson SH, Evans B, Sharma SK, Strakalattis NA, et al. Crystallographic analysis of an active HIV-1 ribonuclease H domain show structural features that distinguish it from the inactive form. Acta Crystallogr 1993; D49:423–427. 96. Prasad VR, Goff SP. Linker insertion mutagenesis of the human immunodeficiency virus transcriptase expressed in bacteria: definition of the minimal polymerase domain. Proc Natl Acad Sci USA 1989; 86:3104–3108. 97. Hizi A, Hughes SH, Shaharabany M. Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase. Virology 1990; 175:575–580. 98. Hizi A, Tal R, Hughes SH. Mutational analysis of the DNA polymerase and ribonuclease H activities of human immunodeficiency virus type 2 reverse expressed in Escherichia coli. Virology 1991; 180:339–346. Page 77 99. Boyer PL, Ferris AL, Clark P, Whitmer J, Frank P, Tantillo C, et al. Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase. J Mol Biol 1994; 243:472–483. 100. Ding J, Jacobo-Molina A, Tantillo C, Lu X, Nanni RG, Arnold E. Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer. J Mol Recognition 1994; 7:157–161. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_77.html (1 of 2) [4/5/2004 4:53:17 PM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Page 63 and 64: Document monophosphate analogs whic
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Page 67 and 68: Document Page 54 Table 2) [12,54].
Page 69 and 70: Document Page 56 It is also attract
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Page 81 and 82: Document Page 67 Biochemical data s
Page 83 and 84: Document Page 69 determining the me
Page 85 and 86: Document Chris Tantillo. The work i
Page 87 and 88: Document Page 72 16. Goldman ME, Nu
Page 89 and 90: Document 30. Coffin JM. HIV populat
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Page 101 and 102: Document 122. Marshall WS, Beaton G
Page 103 and 104: Document dine) and didanosine (dide
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Page 107 and 108: Document 163. Lacey SF, Larder BA.
Page 109 and 110: Document Figure 1 Retroviral lifecy
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Page 113 and 114: Document Page 88 transfer (Figure 3
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Page 117 and 118: Document Page 92 The role of the N-
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Page 121 and 122: Document Page 96 region in the HIV-
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Page 127 and 128: Document Page 101 crystallized unde
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Page 135 and 136: Document Page 108 mulate during tre
Page 137 and 138: Document when metals are bound. Fin
Page 139 and 140: Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Figure 6 Rat and human B2
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Document Figure 9 Composition of te
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Document 39. Mavunkel BJ, Lu Z, Kyl
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document IX. S2' Interactions Page
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Document 7 Structure—Function Rel
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Page 207 sure and the acti
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Document 29. Baker ME. Genealogy of
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Document protein kinase core is ess
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Document 12 Polypeptide Modulators
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Document C. Specificity Figure 4 Th
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Document Figure 5 The S 3 specifici
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Document 17. Szelke M. Chemistry of
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Document 16 Progress in the Design
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Document Table 1 Known Three-Dimens
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Page 412 ture is unlike ot
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 427 These aromatic di
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Document 5. Dinarello CA. On the Bi
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Document 39. Saurat JH, Schfferli J
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Document 74. Bender PE, Lee JC., ed
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Figure 6 Proposed receptor
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Document Page 451 with the cytoplas
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Document for directed subcellular t
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Document Page 462 strains of influe
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Document Page 464 could not again b
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document Page 478 lished—was asso
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Figure 7 HRV14 VP1 hydroph
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Document C. Structure-Activity Rela
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Document Figure 10 Possible hydroge
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Document conformational transition
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Document Page 555 N-acylpyrrolidine
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Document Figure 32 PTP and PTB 3D s
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Document Acknowledgments Page 620 I
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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