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Document 11. (a) Freidinger RM. Progress Drug Res 1993; 40:33–98. (b) Freidinger, RM. Trends Pharm Sci 1989; 10:270–274. 12. Morgan BA, Gainor JA. Ann Rep Med Chem 1989; 24:243–252. 13. Olson GL, Bolin DR, Bonner MP, Bos M, Cook CM, Fry DC, Graves BJ, Hatada M, Hill DE, Kahn M, Madison VS, Rusiecki VK, Sarubu R, Sepinwall J, Vincent GP, Voss ME. J Med Chem 1993; 36:3039–3049. 14. Fairlie DP, Abbenante G, March DR. Current Med Chem 1995; 2:654–686. 15. Wiley RA, Rich DH. Med Res Rev 1993; 13:327–384. 16. Giannis A, Kolter T. Angew Chem Int Ed Engl 1993; 32:1244–1267. 17. Gante J. Angew Chem Int Ed Engl 1994; 33:1699–1720. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_620.html (2 of 2) [4/9/2004 1:43:44 AM]
Document 18. Sawyer TK. In: Peptide-Based Drug Design: Controlling Transport and Metabolism Taylor MD, Amidon GL, Eds. Washington D.C.: ACS Professional Books, American Chemical Society, 1995:387–422. Page 621 19. (a) Shimohigashi Y, Stammer CH. Int J Peptide Protein Res 1982; 20:199–206; (b) Kaur P, Uma K, Balaram P, Chauhan VS. Int J Peptide Protein Res 1989; 33:103–109; (c) Gupta A, Chauhan VS. Int J Peptide Protein Res 1993; 41:421–426. 20. Haghihara M, Anthony NJ, Stout TJ, Clardy J, Schreiber SL. J Amer Chem Soc 1992; 114:6568–6570. 21. Simon RJ, Kania RS, Zuckermann RN, Huebner VD, Jewell DA, Banville S, Ng S, Wang L, Rosenberg S, Marlowe CK, Spellmeyer DC, Tan R, Frankel AD, Santi DV, Cohen FE, Bartlett PA. Proc Natl Acad Sci USA 1992; 89:9367–9371. 22. Freidinger RM, Veber DF, Perlow DS, Brooks JR, Saperstein R. Science 1980; 210:656–658. 23. Nagai U, Sato K. Tet Lett 1985; 26:647–650. 24. Feigl M. J Amer Chem Soc 1986; 108:181–182. 25. Kahn M, Wilke S, Chen B, Fujita K. J Amer Chem Soc 1988; 110:1638–1639. 26. Kemp DS, Stites WE. Tet Lett 1988; 29:5057–5060. 27. Genin MJ, Johnson RL. J Amer Chem Soc 1992; 114:8316–8318. 28. Kahn M, Wilke S, Chen B, Fujita K, Lee YH, Johnson ME. J Mol Recognition 1988; 1(2):75–79. 29. Ripka WC, DeLucca GV, Bach II AC, Pottorf RS, Blaney JM. Tetrahedron 1993; 49:3593–3608. 30. Ripka WC, DeLucca GV, Bach II AC, Pottorf RS, Blaney JM. Tetrahedron 1993; 49:3609–3628. 31. Callahan JF, Newlander KA, Burgess JL, Eggleston DS, Nichols A, Wong A, Huffman WF. Tetrahedron 1993; 49:3479–3488. 32. (a) Smith AB, Keenan TP, Holcomb RC, Sprengeler PA, Guzman MC, Wood JL, Caroll PJ, Hirschmann RS. J Amer Chem Soc 1992; 114:10672–10674; (b) Smith AB, Knight SD, Sprengler PA, Hirschmann Bioorg Med Chem 1996; 4:1021–1034. 33. Cascieri MA, Fond TM, Strader CD. Drugs of the Future 1996; 21:521–527. 34. Pitzele BS, Hamilton RW, Kudla KD, Taymbalov S, Stapefield A, Savage MA, Clare M, Hammond DL, Hansen R DW. J Med Chem 1994; 37:888–896. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_621.html (1 of 2) [4/9/2004 1:44:01 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document Chris Tantillo. The work i
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 92 The role of the N-
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document 4 Bradykinin Receptor Anta
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document 12 Polypeptide Modulators
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Document 16 Progress in the Design
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document B. Protein Structure Page
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Page 739 and 740: Document Figure 22 Protease 3D stru
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Page 743 and 744: Document Page 603 hydroxymethyl sub
Page 745 and 746: Document Page 605 For other serinyl
Page 747 and 748: Document Page 607 scopic studies pr
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Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
Page 761 and 762: Document Page 617 Val (131) showed
Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765: Document Acknowledgments Page 620 I
Page 769 and 770: Document Page 622 Fukuroda T, Fukam
Page 771 and 772: Document Page 623 53. Bird J, Harpe
Page 773 and 774: Document 78. Rodriguez M, Crosby R,
Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783 and 784: Document Page 629 ML, Clare M, Decr
Page 785 and 786: Document Page 630 177. (a) Bode W,
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789 and 790: Document son AH, Drummond AH, Huxle
Page 791 and 792: Document 236. (a) Marshall MS. TIBS
Page 795 and 796: Document 274. (a) Kavanaugh WM, Wil
Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
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Document [Inhibitors] 2-((3,4-dihyd
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Document Kininogen, 119 high molecu
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Document Matrix-metalloproteinase (
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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