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Document References 1. Kuzoe FAS. Current situation of African trypanosomiasis. Acta Trop 1993; 54:153–162. 2. Kuzoe F. African trypanosmiasis. In: Tropical Disease Research Eleventh Programme Report. Geneva: World Health Organization, 1993:57–66. 3. Herwaldt BL, Juranek DD. Laboratory-acquired malaria, leishmaniasis, trypanosomiasis, and toxoplasmosis. Am J Trop Med Hyg 1993; 48:313–323. Page 389 4. Mc Cann PP, Bacchi CJ, Bitonti AJ, Kierszenbaum F, Sjoerdsma A. Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis. Adv Exp Med Biol 1988;250:727–735. 5. Wang CC. Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Annu Rev Pharmacol Toxicol 1995; 35:93–127. 6. Pépin J, Milord F. The treatment of human African trypanosomiasis. Adv Parasitol 1994; 33:1–47. 7. TDR News. 1990; No. 34:1–2. 8. Aldhous P. Fighting parasites on a shoestring. Science 1994; 264:1857–1859. 9. Schechter PJ, Barlow JLR, Sjoerdsma A. Clinical aspects of inhibition of ornithine decarboxylase with emphasis on therapeutic trials of eflornithine (DFMO) in cancer and protozoan diseases. In: Mc Cann PP, Pegg AE, Sjoerdsma A, eds. Inhibition of Polyamine Metabolism. New York: Acad Press, Inc., 1987: 345–364. 10. Borst P, Rudenko G. Antigenic variation in African trypanosomes. Science 1994; 264:1872–1873. 11. Nilsen TW. Trans-splicing in protozoa and helminths. Infect Agents Dis 1992; 1:212–218. 12. Opperdoes FR. Compartmentation of carbohydrate metabolism in trypanosomes. Annu Rev Microbiol 1987; 41:127–151. 13. Verlinde CLMJ, Callens M, Van Calenbergh S, Van Aerschot A, Herdewijn P, Hannaert V, Michels PAM, Opperdoes FR, Hol WGJ. Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structurebased design: toward new drugs for the treatment of sleeping sickness. J Med Chem 1994; 37:3605–3613. 14. Seyfang A, Duszenko M. Specificity of glucose transport in Trypanosoma brucei. Effective inhibition by phloretin and cytochalasin B. Eur J Biochem 1991; 202:191–196. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_389.html (1 of 2) [4/5/2004 5:42:54 PM]
Document 15. Carter NS, Fairlamb AH. Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature 1993; 361:173–176. 16. Ullman B, Allen TE. Hypoxanthine-guanine phosphoribosyltransferase in trypanosomatids: a rational target for antiparasitic chemotherapy. In: Boothroyd J, ed. Molecular Approaches to Parasitology. New York: Wiley-Liss, Inc., 1995:123–141. 17. Wang CC. A novel suicide inhibitor strategy for antiparasitic drug design. J Cell Biochem 1991; 45:49–53. 18. Phillips MA, Coffino P, Wang CC. Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition. J Biol Chem 1987; 262:8721–8727. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_389.html (2 of 2) [4/5/2004 5:42:54 PM]
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document receptor, it has not yet b
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Page 495 and 496: Document Page 398 with growth hormo
Page 497 and 498: Document All effects of the IL-1 fa
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Page 519 and 520: Document Figure 13 The identified p
Page 521 and 522: Document B. Interleukin-1 Receptor
Page 523 and 524: Document Page 423 American Home Pro
Page 525 and 526: Document Page 425 Antinflammatory D
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document [Inhibitors] 2-((3,4-dihyd
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Document Kininogen, 119 high molecu
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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