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Document 46. Hirschmann R, Yao W, Cascieri MA, Strader CD, Maechler L, Cichy-Knight MA, Hynes J Jr, van Rijn RD, Sprengeler PA, Smith AB. J Med Chem 1996; 39:2441–2448. 47. Sawyer TK, Maggiora LL, Liu L, Staples DJ, Bradford VS, Mao B, Pals DT, Dunn BM, Poorman R, Hinzmann J, DeVaux AE, Affholter JA, Smith CW. In: Marshall, GR, Rivier J, Eds. Peptides: Chemistry and Biology Ae Leiden: Escom Science Publishers, 1990; 855–857. 48. Rosenberg SH, Spina KP, Condon SL, Polakowski J, Yao Z, Kovar P, Stein HH, Cohen J, Barlow JL, Klinghofer V, Egan DA, Tricaro KA, Perun TJ, Baker WR, and Kleinert HD. J Med Chem 1993; 36:460–467. 49. (a) McQuade TJ, Tomasselli AG, Liu L, Karacostas V, Moss B, Sawyer TK, Heinrikson RL, Tarpley WG. Science 1990; 247:454–7456; (b) Sawyer TK, Fisher JF, Hester JB, Smith CW, Tomasselli AG, Tarpley WG, Burton PS, Hui JO, McQuade TJ, Conradi RA, Bradford VS, Liu L, Kinner JH, Tustin J, Alexander DL, Harrison AW, Emmert DE, Staples DJ, Maggiora LL, Zhang Y-Z, Poorman RA, Dunn BM, Rao C, Scarbourogh PE, Lowther TT, Craik C, DeCamp D, Moon J, Howe WJ, Heinrikson RL. Bioorg Med Chem Lett 1993; 3:819–824. 50. Roberts NA, Martin JA, Kinchington D, Broadhurst AV, Craig JC, Duncan IB, Galpin SA, Handa BK, Kay J, Krohn A, Lambert RW, Merrett JH, Mills JS, Parkes KEB, Redshaw S, Ritchie AJ, Taylor DL, Thomas GJ, Machin PJ. Science 1990; 248:358–361. 51. Ondetti MA, Rubin B, Cushman DW. Science 1977; 196:441–444. 52. Patchett AA, Harris E, Tristam EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, TenBroeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock, JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Grosse DM, Vassil TC, Stone CA. Nature 1980; 288:280–283. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_622.html (2 of 2) [4/9/2004 1:44:04 AM]
Document Page 623 53. Bird J, Harper GP, Hughes I, Hunter DJ, Karran EH, Markwell RE, Miles-Williams AJ, Rahman SS, Ward RW. Bioorg Med Chem Lett 1995; 5:2593–2598. 54. Porter JR, Beeley NRA, Boyce BA, Mason B, Millican A, Miller K, Leonard J, Morphy JR, O'Connell JP. Bioorg Med Chem Lett 1994; 4:2741–2746. 55. Chapman KT, Durette PL, Caldwell CG, Sperow KM, Niedzwiecki LM, Harrison RK, Saphos C, Christen AJ, Olszewski JM, Moore VL, MacCoss M, Hagmann WK. Bioorg Med Chem Lett 1996; 6:803–806. 56. Edwards PD, Andiskik DW, Strimpler AM, Gomes B, Tuthil PA. J Med Chem 1996; 39:1112–1124. 57. Shuman RT, Rothenberger RB, Campbell CS, Smith GF, Gifford-Moore DS, Gesellechen PD. J Med Chem 1993; 36:314–319. 58. Okamoto S, Hijikata A. J Med Chem 1980; 23:1293–1299. 59. Dolle RE, Prouty CP, Prasad CVC, Cook E, Saha A, Ross TM, Salvino JM, Helaszek CT, Ator MA. J Med Chem 1996; 39:2438–2440. 60. Krausslich H-G, Schneider H, Zybarth G, Carter CA, Wimmer E. J Virology 1988; 2:4394–4397. 61. Owens RA, Gesellchen PD, Houchins BJ, DiMarchi RD. Biochem Biophys Res Comm 1991; 181:401–408. 62. Richards AD, Roberts R, Dunn BM, Graves MC, Kay J. FEBS Letters 1989; 247:113–117. 63. Smith AB, Hirschmann R, Pasternak A, Guzman MC, Yokoyama A, Sprengeler PA, Darke PL, Emini EA, Schleif WA. J Amer Chem Soc 1995; 117:11113–11123. 64. Rich DH, Green J, Toth MV, Marshall GR, Kent SBH. J Med Chem 1990; 33:1288–1295. 65. Kempf J, Sham HL. Current Pharmaceutical <strong>Design</strong> 1996; 2:225–246. 66. Das J, Kimball SD. Bioorg Med Chem 1995; 3:999–1007. 67. Bajusz S, Szell E, Bagdy D, Barbas E, Horvath G, Dioszegi M, Fittler Z, Szabo G, Juhasz A, Tomori E, Szilagyi G. J Med Chem 1990; 33:1729–1735 68. Sherry S, Alkjaersig N, Fletcher AP. Am J Physiol 1995; 209:577–583. 69. Fusetani N, Matsunaga S, Matsumoto H, Takebayashi Y. J Amer Chem Soc 1990; 112:7053–7054. 70. Okamoto S, Hijikata A. J Med Chem 1980; 23:1293–1299. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_623.html (1 of 2) [4/9/2004 1:44:30 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Chris Tantillo. The work i
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Document 106. Cirino NM, Cameron CE
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Table 1 Inhibition Data fo
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822:
Document [Interleukin-1] homology w
Page 823 and 824:
Document Kininogen, 119 high molecu
Page 825 and 826:
Document Matrix-metalloproteinase (
Page 827 and 828:
Document RT inhibitor, 41, 56 Nonpe
Page 829 and 830:
Document Phosphoglycerate kinase (P
Page 831:
Document [Protease targets] serinyl
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