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Document 35. Zablocki JA, Miyano M, Garland B, Pireh D, Schretzman L, Rao SN, Lindmark RJ, Panzer-Knodle S, Nicholson N, Taite B, Salyers A, King L, Feigen L. J Med Chem 1993; 36:1811–1819. 36. Samanen J, Ali FE, Barton L, Bondinell W, Burgess J, Callahan J, Calvo R, Chen W, Chen L, Erhard K, Heyes R, Hwang S-M, Jakas D, Keenan R, Ku T, Kwon C, Lee C-P, Miller W, Newlander K, Nichols A, Peishoff C, Rhodes G, Ross S, Shu A, Simpson R, Takata D, Yellin TO, Uzsinskas I, Venslavasky J, Wong A, Yuan C-K, Huffman W. In: Kaumaya PTP Hodges, RS, Eds. Peptide Chemistry, Structure and Biology Mayflower Scientific Ltd., 1996; 679–681. 37. Flynn DL, Villamil CI, Becker DP, Gullikson GW, Moummi C, Yang D-C. Bioorg Med Chem Lett 1992; 2:1251–1256. 38. Horwell DC. Neuropeptides 1991; 19 (Suppl.):57–64. 39. (a) Ishikawa K, Fukami T, Nagase T, Mase T, Hayama T, Niiyama K, Fujita K, Urakawa Y, Kumagai U, Fukuroda T, Ihara M, Yano M, Eur Peptide Symp, abs. 1992; 27; (b) Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saki T, http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_621.html (2 of 2) [4/9/2004 1:44:01 AM]
Document Page 622 Fukuroda T, Fukami T, Ozaki S, Nagase T, Nishikebe M, Yano M. Proc Natl Acad Sci USA 1994; 91:4892–4896. 40. McDowell RS, Elias KA, Stanley MS, Burdick DJ, Burnier JP, Chan KS, Fairbrother WJ, Hammonds RG, Ingle GS, Jacobsen NE, Mortensen DL, Rawson TE, Won WB, Clark RG, Somers TC. Proc Natl Acad Sci USA 1995; 92:1165–1169. 41. (a) Nicolaou KC, Salvino JM, Raynor K, Pietranico S, Reisine T, Freidinger R, Hirschmann R. In: Rivier JE, Marshall GR, Eds. Peptides-Chemistry, Structure and Biology. Leiden, Netherlands: Escom, 1990:881–884. (b) Hirschmann R, Nicolaou KC, Pietranico S, Salvino J, Leahy EM, Sprengeler PA, Furst G, Smith III AB, Strader CD, Cascieri MA, Candelore MR, Donaldson C, Vale W, Maechler L. J Amer Chem Soc 1992; 114:9217–9218. 42. Hagiwara D, Miyake H, Igarni N. Reg Peptides 1992; 1 (Suppl):66. 43. Smith PW, McElroy AB, Pritchard JM, Deal MJ, Ewan GB, Hagen RM, Ireland SJ, Ball D, Beresford I, Sheldrick R, Jordan CC, Ward P. Bioorg Med Chem Lett 1993; 3:931–935. 44. Boden P, Eden JM, Hodgson J, Horwell DC, Hughes J, McKnight AT, Lewthwaite RA, Prichard MC, Raphy J, Meecham K, Ratcliffe, GS, Suman-Chauhan N, Woodruff GN. J Med Chem 1996; 39:1664–1665. 45. Zablocki JA, Rao SN, Baron DA, Flynn DL, Nicholson NS, Feigen LP. Current Pharm Design 1996; 1:533–558. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_622.html (1 of 2) [4/9/2004 1:44:04 AM]
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Structure-based Drug Design 14 Stru
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 205 enzyme and of phe
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document II. Type IFNs A great deal
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Document B. Protein Structure Page
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Document hydroxy, and 6 Neu5Ac2en -
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Document Subsequent studies have sh
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Document Figure 4 A ribbon diagram
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Page 735 and 736: Document Page 595 the MC1 receptor
Page 739 and 740: Document Figure 22 Protease 3D stru
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Page 743 and 744: Document Page 603 hydroxymethyl sub
Page 745 and 746: Document Page 605 For other serinyl
Page 747 and 748: Document Page 607 scopic studies pr
Page 749 and 750: Document Page 609 (e.g., thermolysi
Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
Page 761 and 762: Document Page 617 Val (131) showed
Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765 and 766: Document Acknowledgments Page 620 I
Page 767: Document 18. Sawyer TK. In: Peptide
Page 771 and 772: Document Page 623 53. Bird J, Harpe
Page 773 and 774: Document 78. Rodriguez M, Crosby R,
Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783 and 784: Document Page 629 ML, Clare M, Decr
Page 785 and 786: Document Page 630 177. (a) Bode W,
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789 and 790: Document son AH, Drummond AH, Huxle
Page 791 and 792: Document 236. (a) Marshall MS. TIBS
Page 795 and 796: Document 274. (a) Kavanaugh WM, Wil
Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document [Interleukin-1] homology w
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Document Kininogen, 119 high molecu
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Document Matrix-metalloproteinase (
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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