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Document 175. (a) Stubbs MT, Bode W. Trends Cardiovasc Med 1995; 5:157–166. (b) Stubbs MT, Bode W. Perspectives in Drug Disc Design 1994; 1:431–452; (c) Bode W, Huber R, Rydel TJ, Tulinsky A. In: Berliner LJ, Ed. Thrombin: Structure and Function. New York: Plenum Press, 1992:3–62; (d) Powers MC, Kam C-M. In: Berliner LJ, Ed. Thrombin: Structure and Function. New York: Plenum Press, 1992:117–158. 176. Weber PC, Lee S-L, Lewandowski FA, Schadt MC, Chang C-H, Kettner CA. Biochem 1995; 34:3750–3757. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_629.html (2 of 2) [4/9/2004 1:47:58 AM]
Document Page 630 177. (a) Bode W, Turk D, Karshikov A, Protein Sci 1992; 1:426–471; (b) Bode W, Mayr I, Baumann U, Huber R, Stone SR, Hofsteenge J. EMBO J 1989; 8:3467–3477; (c) Rydel TJ, Tulinksy A, Bode W, Huber R. J Mol Biol 1991; 221:583–601. 178. Arni RK, Padmanabhan K, Padmanabhan KP, Wu TP, Tulinsky A. Biochem 1993; 32:4727–4737. 179. Maryanoff BE, Qiu X, Pamanhabhan KP, Tulinsky A, Almond HR Jr, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, Burngs PH, Fusetani N. Proc Natl Acad Sci USA 1993; 90:8084–8052. 180. Wiley MR, Chirgadze NY, Clawson DK, Craft TJ, Gifford-Moore DS, Jones ND, Olkowski JL, Schacht AL, Weir LC, Smith GF. Bioorg Med Chem Lett 1995; 5:2835–2840. 181. (a) Brandstetter H, Turk D, Hoeffken HW, Grosse D, Sturzebecher J, Martin PD, Edwards BFP, Bode W. J Mol Biol 1992; 266:1085–1099; (b) Banner DW, Hadvary P. J Biol Chem 1991; 266:20085–20093. 182. Hilpert K, Ackermann J, Banner DW, Gast A, Gubernator K, Hadvary P, Labler L, Muller K, Schmid G, Tachopp TB, van de Waterbeemd H. J Med Chem 1994; 37:3889–3901. 183. Padmanabhan K, Padmanabhan KP, Tulinsky A. J Mol Biol 1993; 232:947–966. 184. (a) Walter J, Steigemann W, Singh TP, Bartunik H, Bode W, Huber R. Acta Cryst 1982; B38:1462–1472; (b) Bode W, Turk D, Sturzebecher J. Eur J Biochem 1990; 193:175–182; (c) Stubbs MT, Huber R, Bode W. FEBS Lett 1995; 375:103–107. 185. Chen ZG, Bode W. J Mol Biol 1983; 164:283–311. 186. Meyer EF. Acta Crystallogr 1988; B44:26–38. 187. Bernstein PR, Andiski D, Bradley PK, Bryant CB, Ceccarelli C, Damewood JR Jr, Earley R, Edwards PD, Feeney S, Gomes BC, Kosmider BJ, Steelman GB, Thomas RM, Vacek EP, Veale CA, Williams JC, Wolanin DJ, Woolson SA. J Med Chem 1994; 37:3313–3326. 188. Edwards PD, Meyer EF Jr, Vijayalakshmi J, Tuthill PA, Andisik DA, Gomes B, Strimpler A. J Am Chem Soc 1992; 114:1854–1863. 189. (a) Navia MA, McKeever BM, Springer JP, Lin T-Y, Williams HR, Fluder EM, Dorn CP, Hoogsteen K. Proc Natl Acad Sci USA 1989; 86:7–11; (b) Takahashi LH, Radhakrishnan R, Rosenfield RE Jr, Meryer EF Jr, Trainor DA, Stein M. J Mol Biol 1988; 201:423–428. 190. Takahashi LH, Radhakrishnan R, Rosenfield RE Jr, Meyer EF, Trainor DA. J Am Chem Soc 1989; 111:3368–3374. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_630.html (1 of 2) [4/9/2004 1:48:30 AM]
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Structure-based Drug Design 14 Stru
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Document 163. Lacey SF, Larder BA.
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document 4 Bradykinin Receptor Anta
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Document We determined the structur
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Document Page 438 proteins. One pot
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Document B. Protein Structure Page
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Page 745 and 746: Document Page 605 For other serinyl
Page 747 and 748: Document Page 607 scopic studies pr
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Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
Page 761 and 762: Document Page 617 Val (131) showed
Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765 and 766: Document Acknowledgments Page 620 I
Page 767 and 768: Document 18. Sawyer TK. In: Peptide
Page 769 and 770: Document Page 622 Fukuroda T, Fukam
Page 771 and 772: Document Page 623 53. Bird J, Harpe
Page 773 and 774: Document 78. Rodriguez M, Crosby R,
Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783: Document Page 629 ML, Clare M, Decr
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789 and 790: Document son AH, Drummond AH, Huxle
Page 791 and 792: Document 236. (a) Marshall MS. TIBS
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Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
Page 823 and 824: Document Kininogen, 119 high molecu
Page 825 and 826: Document Matrix-metalloproteinase (
Page 827 and 828: Document RT inhibitor, 41, 56 Nonpe
Page 829 and 830: Document Phosphoglycerate kinase (P
Page 831: Document [Protease targets] serinyl
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