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Document 71. Sturzebecher J, Markwardt F, Voigt B, Wagner G, Walsmann P. Thromb Res 1983; 29:635–642. 72. Rose C, Vargas F, Facchinetti P, Bourgeat P, Babal RB, Bishop PB, Chan SMT, Moore, ANJ, Ganellin CR, Schwartz J-C. Nature 1996; 380:403–409. 73. Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB. Science 1993; 260:1934–1936. 74. James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, McDowell RS, Crowley CW, Lucas BK, Levinson AD Marsters Jr JC. Science 1993; 260:1937–1942. 75. Qian Y, Blaskovich MA, Seong C-M, Vogt A, Hamilton AD, Sebti SM. Bioorg Med Chem Lett 1994; 21:2579–2584. 76. Scholten JD, Zimmerman K, Oxender GM, Sebolt-Leopold J, Gowan R, Leonard D, Hupe DJ. Bioorg Med Chem 1996; 4:1537–1543. 77. Plummer MS, Lunney EA, Para KS, Vara Prasad JVN, Shahripour A, Singh J, Stankovic CJ, Humblet C, Fergus JH, Marks JS, Sawyer TK. Drug Design Discovery 1996; 13:75–81. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_623.html (2 of 2) [4/9/2004 1:44:30 AM]
Document 78. Rodriguez M, Crosby R, Alligood K, Gilmer T, Berman J. Lett Peptide Sci 1995; 2:1–6. 79. Burke Jr TR, Barchi Jr JJ, George C, Wolf G, Shoelson SE, Yan X. J Med Chem 1995; 38:1386–1396. 80. Burke Jr TR, Kole HK, Roller PP. Biochem Biophys Res Comm 1994; 204:129–134. Page 624 81. (a) Hamilton AD, Sebti SM. Drug News and Perspectives 1995; 8:138–145; (b) Buss JE, Marsters Jr JC. Chemistry and Biology 1995; 2:787–791. 82. Manne V, Yan N, Carboni JM, Tuomari AV, Ricca CS, Brown JG, Andahazy ML, Schmidt RJ, Patel D, Zahler R, Weinmann R, Der CJ, Cox AD, Hunt JT, Gordon EM, Baracid M, Seizinger BR. Oncogene 1995; 10:1763–1779. 83. Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der JD, Hamilton AD, Sebti SM. J Biol Chem 1995; 270:26802–26806. 84. Hunt JT, Lee VG, Leftheria K, Seizinger B, Carboni J, Mabus J, Ricaa C, Yan N, Manne V. J Med Chem 1996; 39:353–358. 85. Botfield MC, Green J. Ann. Rep. Med. Chem 1995; 30:227–237. 86. Kuriyan J, Cowburn D. Current Biology 1993; 3:828–837. 87. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Cou MM, Hanfusa H, Schaffhausen and Cantley LC. Cell 1993; 72:767–778. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_624.html (1 of 2) [4/9/2004 1:45:02 AM] 88. Gilmer T, Rodriguez M, Jordan S, Crosby R, Alligood K, Green M, Kimery M, Wagner C, Kinder D, Charifson P, Hassell AM, Willard D, Luther M, Rusnak D, Sternbach DD, Mehrotra M, Peel M, Shampine L, Davis R, Robbins J, Patel IR, Kassel D, Burkhart W, Moyer M, Bradshaw T, Berman J. J Biol Chem 1994; 269:31711–31719.
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Structure-based Drug Design 14 Stru
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Document Analysis of various HIV-1
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document Page 137 observed for the
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Document Page 141 receptor with int
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document B. Protein Structure Page
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Document hydroxy, and 6 Neu5Ac2en -
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Document Page 476 nM, respectively.
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Page 735 and 736: Document Page 595 the MC1 receptor
Page 739 and 740: Document Figure 22 Protease 3D stru
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Page 743 and 744: Document Page 603 hydroxymethyl sub
Page 745 and 746: Document Page 605 For other serinyl
Page 747 and 748: Document Page 607 scopic studies pr
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Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
Page 761 and 762: Document Page 617 Val (131) showed
Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765 and 766: Document Acknowledgments Page 620 I
Page 767 and 768: Document 18. Sawyer TK. In: Peptide
Page 769 and 770: Document Page 622 Fukuroda T, Fukam
Page 771: Document Page 623 53. Bird J, Harpe
Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783 and 784: Document Page 629 ML, Clare M, Decr
Page 785 and 786: Document Page 630 177. (a) Bode W,
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789 and 790: Document son AH, Drummond AH, Huxle
Page 791 and 792: Document 236. (a) Marshall MS. TIBS
Page 795 and 796: Document 274. (a) Kavanaugh WM, Wil
Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
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Document Kininogen, 119 high molecu
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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