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Document 15. Tilgmann C, Kalkkinen N. Purification and partial sequence analysis of the soluble catechol-Omethyltransferase from human placenta: Comparison to the rat liver enzyme. Biochemical and Biophysical Research Communications 1991; 174:995–1002. 16. Lundström K, Tilgmann C, Peränen J, Kalkkinen N, Ulmanen I. Expression of enzymatically active rat liver and human placental catechol-O-methyltransferase in Escherichia coli; purification and partial characterizaton of the enzyme. Biochimica et Biophysica Acta 1992; 1129:149–154. 17. Tenhunen J, Salminen M, Jalanko A, Ukkonen S, Ulmanen I. <strong>Structure</strong> of the rat catechol-Omethyltransferase gene: separate promoters are used to produce mRNAs for soluble and membranebound forms of the enzyme. DNA and Cell Biology 1993; 12:253–263. 18. Boudikova B, Szumlanski C, Maidak B, Weinshilboum R. Human liver catechol- Omethyltransferase pharmacogenetics. Clinical Pharmacology and Therapeutics 1990; 48:381–389. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_361.html (2 of 2) [4/5/2004 5:30:23 PM]
Document Page 362 19. Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of human soluble and membranebound catechol-Omethyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34:4202–4210. 20. Roth JA. Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the Omethylation of the catecholamine neurotransmitters. Reviews of Physiology, Biochemistry and Pharmacology 1992; 120:1–29. 21. Vidgren J, Svensson LA, Liljas A. Crystal structure of catechol-O-methyltransferase. Nature 1994; 368:354–358. 22. Rossman M, Liljas A, Bränden C I, Banaszak L. Evolutionary and structural relationships among dehydrogenases. In: Boyer PD, ed. Enzymes. New York: Academic Press, 1975:61–102. 23. Schluckebier G, O'Gara M, Saenger W, Cheng X. Universal catalytic domain structure of adometdependent methyltransferases. Journal of Molecular Biology 1995; 247:16–20. 24. Ovaska M. The mechanism of catalysis and inhibition of catechol-O-methyltransferase. Submitted 1996. 25. Bäckström R, Honkanen E, Pippuri A, et al. Synthesis of some novel potent and selective catechol-Omethyltransferase inhibitors. Journal of Medicinal Chemistry 1989; 32:841–846. 26. Borgulya J, Bruderer H, Bernauer K, Zurcher G, Da Prada M. Catechol-O- methyltransferaseinhibiting pyrocatechol derivatives: synthesis and structure- activity studies. Helvetica Chimica Acta 1989; 72:952–968. 27. Nutt JG, Woodward WR, Beckner RM, et al. Effect of peripheral catechol-O- methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994; 44:913–919. 28. Ruottinen H, Rinne UK, Ahtila S, Karlsson M, Kyyrä T, Gordin A. Entacapone increases levodopa response in a one-month double-blind study in parkinsonian patients with fluctuations. Neurology 1995; 45:412S. 29. Ruottinen H, Rinne UK. Entacapone prolongs levodopa response in a one-month double-blind study in parkinsonian patients with levodopa related fluctuations. Journal of Neurology, Neurosurgery, and Psychiatry 1996; 60:36–40. 30. Nutt JG. Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L- DOPA. Advances in Neurobiology. Vol. 69. Philadelphia: Lippincott-Raven Publishers, 1996:493–496. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_362.html (1 of 2) [4/5/2004 5:30:53 PM]
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Structure-based Drug Design 14 Stru
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Document 163. Lacey SF, Larder BA.
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 443 that allowed for
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Document Figure 6 Proposed receptor
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Document Page 451 with the cytoplas
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document C. Structure-Activity Rela
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Document 30. O'Shea EK, Rutkowski R
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Document 22 Peptidomimetic and Nonp
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document MA, Welch KM, Hallak H, Ta
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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