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Document 231. (a) Sun H, Tongs NK. TIBS 1994; 19:480–485; (b) Fry MJ, Panayotou G, Booker GW, Waterfield MD, Protein Sci 1993; 2:1785–1797; (c) Pawson T. Curr Opinion Genet Develop 1992; 2:4–12; (d) Ulrich A, Schlessinger J. Cell 1990; 61:203–212. 232. (a) Taylor SS, Radzio-Andzelm Structure 1994; 2:345–355; (b) Taylor SS, Knighton DR, Zheng J, Sowadski JM, Gibbs CS, Zoller MJ. TIBS 1993; 18:84–89. 233. (a) Mauro LJ, Dixon JE. TIBS 1994; 19:152–155; (b) Feng G-S, Pawson T. Trends Genetics 1994; 10:54–58; (c) Fischer EH, Charbonneau H, Tonks NK. Science 1991; 253:401–406. 234. Shenolikar S. Ann Rev Cell Biol 1994; 10:55–86. 235. (a) O'Keefe SJ, O'Neill EA. Perspect Drug Discovery Des 1994; 2:57–84; (b) Fischer G. Angew Chem Int Ed Engl 1994; 33:1415–1436; (c) Armistead DM, Harding MW. Ann Rep Med Chem 1993; 28:207–215. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_632.html (2 of 2) [4/9/2004 1:49:16 AM]
Document 236. (a) Marshall MS. TIBS 1993; 18:250–255; (b) Milburn MV, Tong L, DeVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim S-H. Science 1990; 247:939–945. 237. (a) Neer EJ. Protein Sci 1994; 3:3–14; (b) Simon MI, Strathmann MP, Gautam N. Science 1991; 252:802–808. Page 633 238. Overduin M, Rios CB, Mayer BJ, Baltimore D, Cowburn D. Cell 1992; 70:69–704. 239. Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J. Cell 1993 72:779–790. 240. Xu RX, Word JM, Davis DG, Rink MJ, Willard MJ Jr, Gampe RT Jr. Biochem 1995; 34:2107–2121. 241. Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD. Cell 1994 77:461–472. 242. Zhou M-M, Meadows RP, Logan TM, Yoon HS, Wade WS, Ravichandran KS, Burakoff SJ, Fesik SW. Proc Natl Acad Sci USA 1995; 92:7784–788. 243. (a) Eck MJ, Shoelson SE, Harrison SC. Nature 1993; 362:87–91; (b) Eck MJ, Atwell SK, Shoelson SE, Harrison SC. Nature 1994; 368:764–769; (c) Mikol V, Baumann G, Keller TH, Manning U, Zurini MGM. J Mol Biol 1995; 246:344–355; (d) Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S. J Mol Biol 1996; 256:601–610. 244. Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. Nature (Struct Biol) 1996; 3:364–374. 245. Lee C-H, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J. Structure 1994; 2:423–438. 246. Rahuel J, Gay B, Erdmann D, Strauss A, Garcia-Echeverria C, Furet P, Caravatti G, Fretz H, Schoepfer J, Grutter MG. Nature (Struct Biol) 1996; 3:586–589. 247. Narula SS, Yuan RW, Adams SE, Green OM, Green J, Philips TB, Zydowsky LD, Botfield MC, Hatada M, Laird ER, Zoller MJ, Karas JL, Dalgarno DC. Structure 1995; 3:1061–1073. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_633.html (1 of 3) [4/9/2004 1:50:03 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document monophosphate analogs whic
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Table 3 HIV-1 RT Amino Aci
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Document Chris Tantillo. The work i
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Document reverse transcriptase inhi
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document -62° for HIV-1 integrase,
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 135 might be jointly
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Figure 5 (a) A cut away vi
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Cyclotheonamide A (CtA), a
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Document A. Chemical Modification P
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Document 16 Progress in the Design
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Figure 11 Functional resid
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 425 Antinflammatory D
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Document Page 427 These aromatic di
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Document 39. Saurat JH, Schfferli J
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Page 747 and 748: Document Page 607 scopic studies pr
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Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
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Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765 and 766: Document Acknowledgments Page 620 I
Page 767 and 768: Document 18. Sawyer TK. In: Peptide
Page 769 and 770: Document Page 622 Fukuroda T, Fukam
Page 771 and 772: Document Page 623 53. Bird J, Harpe
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Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783 and 784: Document Page 629 ML, Clare M, Decr
Page 785 and 786: Document Page 630 177. (a) Bode W,
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789: Document son AH, Drummond AH, Huxle
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Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
Page 823 and 824: Document Kininogen, 119 high molecu
Page 825 and 826: Document Matrix-metalloproteinase (
Page 827 and 828: Document RT inhibitor, 41, 56 Nonpe
Page 829 and 830: Document Phosphoglycerate kinase (P
Page 831: Document [Protease targets] serinyl
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