tratado_fibro_quistica

402 ALTERACIÓN DE LA DENSIDAD MINERAL ÓSEA
sobre los posibles factores contribuyentes, como promover el ejercicio, la suplementación de vitamina K y vitamina
D, especialmente en invierno, una adecuada ingesta de calcio y mejorar el estado nutricional. Las modalidades
terapéuticas actuales según los protocolos establecidos se centran en los bifosfonatos, aunque existe menos experiencia
en niños, y la terapia hormonal en el caso de retraso puberal. El papel de la PTH recombinante humana
todavía está por establecer.
BIBLIOGRAFÍA
1. Conway SP, Morton AM, Oldroyd B, Truscott
JG, White H, Smith AH, et al. Osteoporosis
and osteopenia in adults and adolescents
with cystic fibrosis: prevalence and associated
factors. Thorax. 2000;55(9):798-
804.
2. Bone mineralisation in cystic fibrosis. Report
of the UK Cystic Fibrosis Trust Bone
Mineralisation Working Group. February
2007.
3. Rico H. La formación ósea su modelación y
remodelación. En: Diéguez C, Iturriaga R,
eds. Metabolismo fosfocálcico. Actualizaciónes
en endocrinología 9. Madrid: Mc-
Graw Hill Interamericana; 2003. p. 25-35.
4. Chang J, Wang Z, Tang E, Fan Z, McCauley
L, Franceschi R, et al. Inhibition of osteoblastic
bone formation by nuclear factorkappaB.
Nat Med. 2009;15(6):682-9.
5. Pérez R, Segura MC. Regulación del metabolismo
mineral: PTH, calcitonina,vitamina
D. En: Diéguez C, Iturriaga R, eds. Metabolismo
fosfocálcico. Actualizaciónes en
endocrinología 9. Madrid: McGraw Hill Interamericana;
2003. p. 1-23.
6. Matsuo K, Irie N. Osteoclast-osteoblast
communication. Arch Biochem Biophys.
2008;473(2):201-9.
7. Lambert JP. Osteoporosis: a new challenge
in cystic fibrosis. Pharmacotherapy.
2000;20(1):34-51.
8. Elkin SL, Vedi S, Bord S, Garrahan NJ,
Hodson ME, Compston JE. Histomorphometric
analysis of bone biopsies
from the iliac crest of adults with cystic
fibrosis. Am J Respir Crit Care Med.
2002;166(11):1470-4.
9. Haworth CS, Webb AK, Egan JJ, Selby PL,
Hasleton PS, Bishop PW, et al. Bone histomorphometry
in adult patients with cystic
fibrosis. Chest. 2000;118(2):434-9.
10. Haworth CS. Impact of cystic fibrosis
on bone health. Curr Opin Pulm Med.
2010;16(6):616-22.
11. Sparks AA, McGee SJ, Boone CE, Neuringer IP,
Jones SK, Aris RM. ‘Old’ bones in young bodies:
the tale of cystic fibrosis. Curr Opin Endocrinol
Diabetes Obes. 2009;16(6):407-14.
12. Cystic Fibrosis Foundation, Patient Registry
2006 Annual Report, Bethesda, Maryland. p.
1-17.
13. Shead EF, Haworth CS, Condliffe AM, McKeon
DJ, Scott MA, Compston JE. Cystic fibrosis
transmembrane conductance regulator
(CFTR) is expressed in human bone.
Thorax. 2007;62(7):650-1.
14. Le Heron L, Guillaume C, Velard F, Braux
J, Touqui L, Moriceau S, et al. Cystic fibrosis
transmembrane conductance regulator
(CFTR) regulates the production of
osteoprotegerin (OPG) and prostaglandin
(PG) E2 in human bone. J Cyst Fibros.
2010;9(1):69-72.
15. Pashuck TD, Franz SE, Altman MK, Wasserfall
CH, Atkinson MA, Wronski TJ, et al. Murine
model for cystic fibrosis bone disease
demonstrates osteopenia and sex-related
differences in bone formation. Pediatr Res.
2009;65(3):311-6.
16. Bronckers A, Kalogeraki L, Jorna HJ, Wilke
M, Bervoets TJ, Lyaruu DM, et al. The cystic
fibrosis transmembrane conductance
regulator (CFTR) is expressed in maturation
stage ameloblasts, odontoblasts and
bone cells. Bone. 2010;46(4):1188-96.
17. Borowitz D, Baker RD, Stallings V. Consensus
report on nutrition for pediatric
patients with cystic fibrosis. J Pediatr Gastroenterol
Nutr. 2002;35(3):246-59.
18. Stallings VA, Stark LJ, Robinson KA, Feranchak
AP, Quinton H; Clinical Practice Guidelines on
Growth and Nutrition Subcommittee; Ad Hoc
Working Group. Evidence-based practice
recommendations for nutrition-related management
of children and adults with cystic
fibrosis and pancreatic insufficiency: results
of a systematic review. J Am Diet Assoc.
2008;108(5):832-9.
19. Cystic Fibrosis Foundation, Borowitz D,
Robinson KA, Rosenfeld M, Davis SD, Sabadosa
KA, et al. Cystic Fibrosis Foundation
evidence-based guidelines for management
of infants with cystic fibrosis. J Pediatr.
2009;155(6 Suppl):S73-93.
20. Grey V, Atkinson S, Drury D, Casey L,
Ferland G, Gundberg C, et al. Prevalence
of low bone mass and deficiencies of
vitamins D and K in pediatric patients with
cystic fibrosis from 3 Canadian centers.
Pediatrics. 2008;122(5):1014-20.
21. Khazai NB, Judd SE, Jeng L, Wolfenden LL,
Stecenko A, Ziegler TR, et al. Treatment
and prevention of vitamin D insufficiency
in cystic fibrosis patients: comparative
efficacy of ergocalciferol, cholecalciferol,
and UV light. J Clin Endocrinol Metab.
2009;94(6):2037-43.
22. Conway SP, Wolfe SP, Brownlee KG, White H,
Oldroyd B, Truscott JG, et al. Vitamin K status
among children with cystic fibrosis and its relationship
to bone mineral density and bone
turnover. Pediatrics. 2005;115(5):1325-31.
23. Curran DR, McArdle JR, Talwalkar JS. Diabetes
mellitus and bone disease in cystic
fibrosis. Semin Respir Crit Care Med.
2009;30(5):514-30.
24. Manolagas SC, Jilka RL. Bone marrow, cytokines,
and bone remodeling. Emerging insights
into the pathophysiology of osteoporosis.
N Engl J Med. 1995;332(5):305-11.
25. Aris RM, Stephens AR, Ontjes DA, Denene
Blackwood A, Lark RK, Hensler MB, et
al. Adverse alterations in bone metabolism
are associated with lung infection in adults
with cystic fibrosis. Am J Respir Crit Care
Med. 2000;162(5):1674-8.
26. Aris RM, Renner JB, Winders AD, Buell HE,
Riggs DB, Lester GE, et al. Increased rate
of fractures and severe kyphosis: sequelae
of living into adulthood with cystic fibrosis.
Ann Intern Med. 1998;128(3):186-93.
27. Rossini M, Del Marco A, Dal Santo F,
Gatti D, Braggion C, James G, et al. Prevalence
and correlates of vertebral fractures
in adults with cystic fibrosis. Bone.
2004;35(3):771-6.
28. Elkin SL, Fairney A, Burnett S, Kemp M, Kyd
P, Burgess J, et al. Vertebral deformities
and low bone mineral density in adults with
cystic fibrosis: a cross-sectional study. Osteoporos
Int. 2001;12(5):366-72.
29. Paccou J, Zeboulon N, Combescure C, Gossec
L, Cortet B. The prevalence of osteoporosis,
osteopenia, and fractures among adults
with cystic fibrosis: a systematic literature
review with meta-analysis. Calcif Tissue Int.
2010;86(1):1-7.
30. Erkkila JC, Warwick WJ, Bradford DS. Spine
deformities and cystic fibrosis. Clin Orthop
Relat Res. 1978;(131):146-50.
31. Haworth CS, Selby PL, Horrocks AW,
Mawer EB, Adams JE, Webb AK. A prospective
study of change in bone mineral
density over one year in adults with cystic
fibrosis. Thorax. 2002;57(8):719-23.
32. Aris RM, Merkel PA, Bachrach LK, Borowitz
DS, Boyle MP, Elkin SL, et al. Guide to bone
health and disease in cystic fibrosis. J Clin
Endocrinol Metab. 2005;90(3):1888-96.
33. Kelly TL, Specker BL, Binkely T, Zemel BS,
Leonard MB, Kalkwarf HJ, et al. Pediatric BMD
reference database for US white children. J
Bone Miner Metab. 2005;36(S1):1-101.
34. Carrascosa A, Rio L, Gussinye M, Yeste D,
Audi L. Mineralización del esqueleto óseo
durante la infancia y adolescencia. Factores
reguladores y patrones de normalidad. An
Esp Pediatr. 1994;40:246-52.