Rapporten - SBU

Table 3.1.17 continued
Author
Year
Reference
Country
Corsello et al
2007
[18]
USA/
United
Kingdom
Aim Study design
Population characteristics
Setting
Disease prevalence
Drop-out
To investigate how
well the SCQ func-
tions as a clinical
screening instrument
in a young
sample of children
with ASD or non-
ASD disorders
To compare SCQ
with the ADI-R
regarding its discriminating
validity
both alone and in
combination with
the ADOS
Study design
Cross-sectional
Population characteristics
N=590
Children with possible ASDs
consecutively referred
Autism: n=282
PDD-NOS: n=157
Non-PDDs: n=151
IQ: significantly lower verbal and
non-verbal IQ scores in the Autism
group than the PDD-NOS and
non-ASD groups, and significantly
lower verbal and non-verbal IQ
scores in the non-ASD group
than in the PDD-NOS group.
Age range: 2–16 years
Gender: 78% male
Setting
2 tertiary university clinics
Disease prevalence
ASD: 75%
Autism: 48%
Drop-out
43 participants were excluded
because of missing SCQ items
130 Autismspektrumtillstånd – diAgnostik och insAtser,
KAPITEL 3 • sysTEmATIsK LITTErATurövErsIKT –
131
vårdens orgAnisAtion och pAtientens delAktighet
Index test Reference test Main findings Study quality Comments
SCQ Diagnoses were made
by examiners who had
access to all assessments
results. The examiners
were blind to
SCQ scores but aware
of ADI-R and ADOS
scores and
classifications
Parents completed
the SCQ prior to the
ADI-R interview
SCQ cut-off >15
ASD vs non-ASD
Se: 0.71
Sp: 0.71
Autism vs non-autism
Se: 0.78
Sp: 0.57
SCQ cut-off >22
Autism vs Non-ASD
Se: 0.45
Sp: 0.84
InsTrumEnT för uTrEdnIng Av AsT
When the cut-off ≥15 was
used the SCQ resulted in
lower Se than the ADI-R
which is not ideal for a
screening measure
The SCQ was most effective
in the 8–10 and >11
years age groups
Younger children scored
lower than older children
with ASDs on the
SCQ, with the SCQ (≥15
missing a large number
of younger children with
ASDs
Moderate Participants in
the autism group
were significantly
younger than in
the PDD-NOS
group
Significant difference
across
groups with
more males
than females
in the Autism
and PDD-NOS
groups than the
non-ASD
Sample may not
be representative
of children referred
to general
psychiatric or
developmental
clinics
The sample size
for children