Rapporten - SBU

Table 3.1.18 continued
Author
Year
Reference
Country
Constantino
et al
2007
[21]
USA
Aim Study design
Population characteristics
Setting
Disease prevalence
Drop-out
This study examined
the application
of the SRS
in the classroom
setting
Study design
Prospective study, patients
chosen at random from
clinical listings.
Parents were mailed two
SRS forms per child to be
completed by the parent(s)
and by one of the child’s
teachers
Population characteristics
Parents and teachers of 577
children from 323 families currently
enrolled in another study
Data analysis comprised PDD
n=271,
Unaffected siblings n=119,
Non-PDD controls n=52
Age range: 10.1–11.9 years
Gender: Unknown
IQ data were available
for 126 of the subjects
Setting
Tertiary clinic
(university clinic)
Prevalence
ASD 48%
Drop-outs
18% of the families
ASD = Autism spectrum disorder; ADI-R = Autism diagnostic interview-revised; ADOS
= Autism diagnostic observation schedule; DSM-IV = Diagnostic and statistical manual of
mental disorders, fourth version; ICD-10 = International Classification of Diseases and
Related Health Problems, version 10; IQ = Intelligence quotient; N = Number of patients;
PDD = Pervasive developmental disorders; SD = Standard deviation; Se = Sensitivity; Sp =
Specificity; SRS = Social responsiveness scale;
136 Autismspektrumtillstånd – diAgnostik och insAtser,
KAPITEL 3 • sysTEmATIsK LITTErATurövErsIKT –
137
vårdens orgAnisAtion och pAtientens delAktighet
Index test Reference test Main findings Study quality Comments
SRS ADI-R, and in,
a majority of cases,
the ADOS, or expert
clinician diagnosis
PDD-diagnosis:
A SRS T-score of >60
by both parent and
teacher report:
Se: 0.75
Sp: 0.96
Likelihood of a clinically
classified PDD
diagnosis is 96.8% and
false positive rate 3.2%
The SRS T-score of 60
exclusively by parent
report:
Se: No data
Sp: 0.84
Exclusively teacher
report:
Se: No data
Sp: 0.90
Inter-rater agreement
between parents and
teachers r=0.72
InsTrumEnT för uTrEdnIng Av AsT
Moderate Limitations:
Small sample.
Low proportion
of females.
Discrepancies
in age between
various diagnostic
groups
The SRS were
completed by the
mother, father,
and a teacher 2–6
weeks after an
ADI-R interview
with the mother.
Research assistants
were blind to clinical
DSM-IV criteria
diagnosis