Rapporten - SBU

Table 3.1.17 continued
Author
Year
Reference
Country
Eaves et al
2006
[19]
Canada
Aim Study design
Population characteristics
Setting
Disease prevalence
Drop-out
To examine
the validity of the
SCQ in two young
clinical samples
Study design
Cross-sectional study
Population characteristics
N=151
IQ 33.6% were intellectually disabled
Age range: 3–7 years
Children under the age of 3 years
were excluded
Gender: 79% male
Setting
Tertiary autism clinic (university
clinic) or preschool clinics
Disease prevalence
ASD 32%
Drop-out
None reported
ASD = Autism spectrum disorder; ADI-R = Autism diagnostic interview-revised; ADOS =
Autism diagnostic observation schedule; CARS = Childhood autism rating scale; DSM-IV
= Diagnostic and statistical manual of mental disorders, fourth version; IQ = Intelligence
132 Autismspektrumtillstånd – diAgnostik och insAtser,
KAPITEL 3 • sysTEmATIsK LITTErATurövErsIKT –
133
vårdens orgAnisAtion och pAtientens delAktighet
Index test Reference test Main findings Study quality Comments
SCQ Autism diagnoses
relied on the use of
the CARS, the ADI-R
and clinical judgement,
and in some cases the
ADOS
Diagnoses were made
an experienced team of
expert clinicians
The ADI-R was not
used in arriving at
the final diagnosis
ASD diagnosis,
cut-off of 15:
Se: 0.71
Sp: 0.79
Preschool clinics n=45
ASD diagnosis:
Se: 0.71
Sp: 0.76
Autism clinic n=106
ASD diagnosis:
Se: 0.71
Sp: 0.52
Overall
n=151
PPV: 65%
InsTrumEnT för uTrEdnIng Av AsT
The SCQ cut-off of 15
yielded a hit rate of 65%
in sorting out ASD from
non-ASD. 28% of the
children with ASD were
missed and 38% of the
non-ASD were misidentified
as having ASD
Higher functioning children
with ASD are less
likely to be identified by
the SCQ
If the cut-off score
is reduced to 11, Se
increases but Sp
declines unacceptably
Moderate Limitations: the
ADI-R was used
in the clinical
work-up by the
experts making
the final clinical
diagnosis
quotient; LR+ = Positive likelihood ratio; LR– = Negative likelihood ratio; N = Number
of patients; PDD = Perrasive developmental disorders-not otherwise specified; PPV =
Positive predictive value; SCQ = Social communication questionnaire; Se = Sensitivity;
Sp = Specificity