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Processing and Bioavailability (WG2) page 62
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Table 8. Human studies on the intestinal absorption of lycopene using multiple doses
Dosage Matrix Result Reference
5 mg/d, 6 w · Tomatoes (80 - 230 g/d)
· Tomato juice (59 g/d)
· Capsules
Lycopene better
available from tomato
juice and capsules
Böhm et al.,
1999
12 mg/d, 6 w · Tomato juice (180 ml/d) No effect Micozzi et al.,
1992
16,5 mg/d, 7 d · Tomato purée (60 g/d)
· Tomatoes (300 g/d)
39 - 75 mg/d, 1 w · Spaghetti sauce (126 g/d)
· Tomato juice (540 ml/d)
· Lycopene capsules
Lycopene better
available from purée
Porrini et al.,
1998
Lycopene in serum ↑ Agarwal et al,
1998
40 mg/d, 2 w · Tomato juice (330 ml/d) Lycopene in plasma ↑ Müller et al.,
1999
70 - 75 mg/d, 4 w · Tomato juice (476 g/d)
· Capsules
Lycopene in plasma ↑ Paetau et al.,
1998
Figure 5 shows the plasma response after multiple doses of 5 mg/d lycopene comprised in
capsules, tomatoes or tomato juice. Lycopene is significantly better absorbed from tomato
juice and oleoresin capsules compared to raw tomatoes.