NO - Besoin d'assistance

Observational epidemiological surveys (WG 3) page 11
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cancer sites World Cancer Res Carotenoids
Fund (USA, 1997) (I A R C, 1998)
mouth and
NM insufficient
pharynx
1: - ; 1: 0
larynx NM insufficient
1: -
oesophagus NM insufficient
1: (-)
lung NM insufficient
1: 0
colon-rectum NM insufficient
1: -
pancreas NM insufficient
1: -
breast NM inconsistent
2: (-); 1: 0
ovary NM insufficient
1: (+)
cervix NM inconsistent
1: (-); 1: 0
prostate insufficient
insufficient
1:+
1:(-)
bladder NM insufficient
1:+
skin NM no relationship
4: 0
*the figures indicate the number of studies, -: a significant risk
reduction; (-): a non significant risk reduction; 0: no relationship;
+: a significant increased risk; (+): a non significant increased risk.
NM: Not Mentioned
Comparison between tables 1, 3 and 4
The evidence for a protective effect of tomato intake was stronger than for lycopene,
especially for oesophagus, stomach and lung cancers, where this effect is judged
« convincing ». Studies with lycopene have been less frequent, and the comment was mostly
« insufficient ». But, when there were three studies (breast cancer) or more (skin cancer), the
results were inconsistent. Therefore it is possible that other compounds present in tomatoes
also play a protective role. These other compounds are essentially β-carotene, vitamins C and
E, folates and phenolics. We will describe the relationship of cancers with β-carotene,
vitamins C and E as reported in epidemiological studies.