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Observational epidemiological surveys (WG 3) page 33
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1-2-5 Vitamin C (Tables 19-21)
Comments on Table 19-21
Except for the case-control study on lung cancer in Uruguay (De Stefani et al., 1999) and the
prospective study of Eicholzer et al. (1996), only 24 cases with stomach cancer, recent case-
control prospective studies confirmed the conclusion of the three reference books on the risk
reduction conferred by vitamin C for cancers of the upper aero-digestive tract including
stomach, lung and respiratory tract cancers. But association for a greater effect with other
antioxidants was often reported, emphasising again the importance of association of
antioxidants. For colon cancer, we remain with insufficient and/or inconsistent data. For
breast cancer, results were borderline in two Mediteranean case-control studies and non-
significant in two prospective North-American and North-European studies. Again the
Uruguayan results Ronco et al., 1999; Deneo-Pelligrini et al., 1999 are at odds with other
studies on breast cancer and prostate cancer. It might be that vitamin C is coufounded by
another microconstituant of fruit and vegetables.
Comparison between tables 9 and 19-21 (Same comments as for tables 9 and 15-18).