NO - Besoin d'assistance

Observational epidemiological surveys (WG 3) page 64
_________________________________________________________________________________________
CI:0.68-1.16), (Table 36), but a decreasing trend with higher consumption was borderline
significant (p=0.07).
4.2 Lycopene
Serum lycopene was found not to be significantly associated with decreased risk of cataract
(OR = 1.1, CI 0.5-2.6; Lyle, B.J. et al. 1999). Furthermore, high intake of lycopene was
related to more severe nuclear sclerosis (Mares-Perlman et al., 1995) attaining statistical
significance in women (OR = 1.49, CI:1.01 - 2.19, p < 0.05). But some critics were brought
up such as the non-adjustment on energy, the only use of multivariate analysis. Indeed, in a
follow-up of the same study, such an association was not found, but the protective effect of
lutein remained (Lyle et al., 1999). Significant protective effects of lycopene were neither
detected for catarct extraction on Health Professional Follow-up Study (Brown et al.,1999)
and Nurses’ Health Study (Chasan-Taber et al., 1999). However, in the former study a
significant decreasing trend (p= 0.05) of nuclear cataract has been shown in men with
increasing lycopene intake (Table 37).