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Observational epidemiological surveys (WG 3) page 28
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Table 15: Carotenoids and cancers. Recent case-control studies based on dietary intake
Cancer sites Authors and
Country
OR (CI) Trend Remarks
year
Design
Salivary gland Horn-Ross et
USA
carotene H (>3.9mg/day) vs L (≤2.1 0.05 becomes NS after adjustment for
al., 1997 cases: 133; controls: 191 mg/day) 0.54 (0.29-0.99)
vitamin C
Mouth and pharynx Bosetti et al., Italy and Switzerland β-carotene H vs L (not defined) 5mg/day)
0.05 vitamin C+E+b-carotene: squamous
2000 cases:185 adenocarc.; vs L (≤0.7mg/day) 0,6 (0.4-1.0) for
id; oesophagus adenocarc.: OR: 0.5
165:squamous cell carc.;. squamous cell carc., 0.5 (0.3-0.8) for
(0.3-0.9) trend: 0.009 for
controls: 815
adenocarc.
0.0005
Stomach Ji et al., 1998 China
M:H (≥1.5 mg/day) vs L (≤0.74) 0.4 M adjustment for alcohol and tobacco
cases: 1124 controls: 1451 (0.3-0.6); F: H (1.3mg/day) vs L