NO - Besoin d'assistance

Mechanisms and Biomarkers (WG 4) page 38
__________________________________________________________________________________________
Chapter 3. Tomato Carotenoids: A Mechanistic Approach to Redox Functions
INTRODUCTION
The tomato contains a complex mixture of nutrients and micronutrients, which interact during
digestion and uptake to confer protection to wide variety of tissues, following toxic insults.
Attempts to isolate and study the individual components have yet to unequivocally support
the apparent benefits of consuming a Mediterranean type diet. The clear health benefits of
fruit and vegetable consumption conceal a complex mass of interacting variables. A
simplified understanding of these interactions forms the basis of the network philosophy.
Although this network focuses on lycopene as the most important tomato component we must
be receptive to potentially valuable synergies that may exist between lycopene and the other
antioxidants or protective components such as vitamin C, vitamin E, polyphenols, flavonoids
and folic acid.
Future studies must seek to establish a unifying theme for the role of dietary protective agents.
MECHANISMS
Gap junctions
Gap junctions are small, narrow hydrophilic pores connecting the cytosol of adjacent cells.
These pores allow the intracellular transport of small molecules (