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Table 38 Carotenoids and cataract
Observational epidemiological surveys (WG 3) page 68
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Authors, year and number of
subjects
Odds ratio and CI Comments
Jacques and Chylak, 1991 (n = 77) high (>3.3 µmol/L) vs low plasma
total carotenoids (< 1.7 µmol/L)
0.18 (0.03 - 1.03)
no effect of β carotene
Hankinson et al., 1992 (n = 50 828)
cataract surgery
High (14 558 IU/d)vs low (2935
IU/d) of carotenes intake
0.73 (0.55 - 0.97)
Vitale et al., 1994 (n = 671) high (>0.88 µmol/L) vs low plasma
β-carotene (< 0.33 µmol/L
nuclear cataract 1.57 (0.84 - 2.93)
Teikari et al., 1998 (n = 28 934)
(50 - 69 years); intervention
followed for 5 to 8 years
Brown et al., 1999 (n = 36 664)
Health Professionnals Follow-up
Study; men (45-75 y);
Lyle et al., 1999a (n=1349)
Beaver Dam Eye Study
Lyle et al., 1999b (n=400)
Beaver Dam Eye Study
Chasan-Taber et al., 1999 (n = 77
466)
Nurses' Health Study; women (45 -
71 years)
cortical cataract 0.72 (0.37 - 1.42)
advanced cataract
β-carotene supplementation vs
placebo;
0.97 (0.79 - 1.19)
carotene supplements
low (3777 IU) vs high (18499)
cataract extraction 0.85 (0.68 -
1.07)
high intake (1.245mg/kcal) vs low
(0.3)
0.5 (0.3-0.8) trend 0.002
all carotenoids plasma levels NS
0.3 (0.1-1.2) trend 0.13
carotene supplements
low (2944 IU) vs high (14 583);
0.85 (0.72 - 1.00) ns
no association with carrots
associated with low spinach intakes
adjusted on age, sex and diabetes
male smokers
multivariate relative risk.
no effect of β-carotene
all carotenoids NS excepted lutein
lutein borderline in >65 years
multivariate relative risk.
cataract extraction; no effect of βcarotene