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Observational epidemiological surveys (WG 3) page 55
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Table 31: Prospective studies based on serum vit C levels
Authors country
n cases
M or F, age
Vita et al.,
(1998)
case study
Simon et al.,
(1998)
Sahyoun et al.,
(1996)
Nyssonen et al.,
(1997)
Gale et al.,
(1995)
(Follow-up)
Country ?
149 cases
M + F
Age ?
NHANES II
6624 US adults
M+F, 40-74
Massachusetts
747
Elderly
M+F, >60
9-12 years
Finland
1606
M, 42-60
5 years
British elderly
730
M+F, > 65
outcome exposure
measurement
Unstable
coronary
syndrome
CHD
Stroke
Peripheral
vascular
disease
CHD
Total
mortality
12 plasma markers of AO/ox
status, correlation with
atherosclerosis
Results OR, comparison
group, CI, P trend
Low vit C plasma levels were
significant predictors of unstable
coronary syndrome
OR=0.59 (0.40-0.89), p=0.01
Serum vit C H vs L CHD : 0.73 (0.59-0.90)
Stroke: 0.74 (0.56-0.97)
Plasma vit C (together with vit E
and carotenoids)
T5/1 plasma vit C
OR=0.54 (0..32-0..90)
MI Plasma vit C Low vs high serum vit C:
Adjusted OR=2.5 (1.3-5.2),
CHD
stroke
Plasma vit C + No association
Check for plasma values
remarks
Antioxidants may
slow down
progression of
atherosclerosis
the effect of vitamin
C is observed only at
saturated levels of
plasma vit C; No
effect on peripheral
vascular disease
High plasma vit C
levels may protect
against early
mortality and
mortality from CHD
Vit C deficiency
(low serum levels) is
a risk factor for
CHD.
Normal to high
plasma vit C showed
no difference in risk
Vit C conc is
strongly related to
subsequent risk of
death from stroke but
not from CHD