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Observational epidemiological surveys (WG 3) page 51
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Table 28 Case-control and prospective studies based on carotenoids serum or adipose-tissue levels
First Author
(year)
Kardinaal et
al., (1993)
Morris et al.,
(1994)
Street et al.,
(1994)
Sahyoun et
al., (1996)
Iribarren et
al., (1997)
Kohlmeier et
al., (1997)
Country
n case (control)
M or F age
EURAMIC
(multicentric
study) 683 (727)
LRC-CPPT
M 266 (1 899)
40-59y
USA
125 (25 802)
35-65y
USA
(747)
Minnesota
(261)
EURAMIC
10 european
countries
outcome exposure
measurement
Fatal CVD,
non-fatal
MI
Adipose βcar
0.35µg/g in case
0.42µg/g in controls
serum carotenoids
3.2 µM/l
results
OR and OR
p trend
L vs H: OR=1.78
(1.17-2.71)
P trend 0.001
OR= 0.64 (0.44-
0.92), 0.28 (0.11-
0.73) for never
smokers
IMI plasma βcar OR= 0.45(0.22-0.90)
P trend 0.03
ACVD plasma OR= NS
death
trend NS
LDL serum carotenoids OR =0.75 (0.59-0.94)
oxidation and vitamins βcrypto
IMT
OR = 0.76 (0.59-
0.95) lut+zea
OR=0.81 (0.60-1.08)
for lycopene
MI adipose tissue OR=0.52
(0.33-0.82) for lyc
Remarks
Association strongest
among current & exsmokers
13 years
plasma βcar and vit E
inv. related to carotid
artery wall thickness
7-14y
βcar, lut and zea were
inversely correlated to
atherosclerosis
α and βcar eliminated
for associations βcar