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Mechanisms and Biomarkers (WG 4) page 29
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Inflammatory immune/
autoimmune conditions
Cataractogenesis
Retinal degeneration
Premature retinopathy
Rheumatoid arthritis
Glomerular nephritis
HIV/Aids
Vasculitis
Autoimmune nephrotic syndromes
Ischaemia/Reperfusion Myocardial infarction
Organ transplantation
Circulatory obstruction in crash victims
Thrombophlebitis
Kidney Fe-mediated nephrotoxicity
Aminoglycoside toxicity
Lung Bronchial dysplasia
Mineral dust pneumoconiosis
Hypoxia
Cigarette smoke
Emphysema
ARDS (adult respiratory distress syndrome)
Table 1., although not an exhaustive list, gives an indication of the importance of free radicals
in the aetiology of many degenerative conditions and disease states, and highlights the need
for more rigorously conducted experimental dietary studies in humans, where the chosen
biomarkers give an unequivocal measure of intermediate end-points related to disease risk.