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Mechanisms and Biomarkers (WG 4) page 2
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Mission Statement:
The brief of WG4 has been to carry out research and collate data to provide supporting
mechanistic evidence for the WG3 epidemiological programme, to assess the current state of
biomarker research, and to evaluate the role of tomato antioxidants in healthy diets to support
the aims of WG1 and WG2 in the optimisation of crop quality, product composition and
process control.
Review Structure:
In chapter 1 Edmond Rock introduces the chemistry of oxygen radicals and their role in
oxidative stress.
Chapter 2 by Rod Bilton further elaborates the biomarker concept and examines the function
of oxygen radicals and ‘active species’ in oxidative cellular damage.
In chapter 3 Gordon Lowe reviews current mechanistic evidence for the purported protective
functions of the major tomato carotenoids against oxidative stress.
Finally in chapter 4 Marisa Porrini and Patrizia Riso present evidence for the protective role
of tomato products in healthy diets, in a comprehensive review of recent human dietary
intervention studies.
Further support was provided by Mariette Gerber and Elizabeth Offord who supplied
additional reference material and critical analysis of the review chapters.