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Observational epidemiological surveys (WG 3) page 41
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Table 25: Vitamin E and cancers. Recent prospective studies on tissue concentrations
Cancer sites Authors and
year
Stomach Eichholzer et
al.,
1996
Lung Eichholzer et
al.,
1996
Woodson et al.,
1999
Colon Eichholzer et
al.,
1996
Prostate Eichholzer et
al.,
1996
Gann et al.,
1999
Country
Design
Switzerland
prospective(17)
24/2974
Switzerland
prospective(17)
83/2974
Finland
(7.7)
1144/29102
Switzerland
prospective(17)
21/2974
Switzerland
prospective
(17)
29/2974
USA
Physician’s
Health Study
cases: 578;
matched
controls: 1294
OR Trend Remarks
plasma conc.
L (30.02µm/l)
0.52 (0.20-1.34)
plasma conc.
L (30.02µm/l)
1.03 (0.60-1.78)
plasma conc.
H (10mg/l)
0.81 (0.67-0.97)
plasma conc.
L (30.02µm/l)
1.33 (0.47-3.80)
plasma conc.
L (30.02µm/l) +
smokers:19.89 (3.6-109-8)
non smokers: 5.66 (0.88-36.34)
H(cut off point:33.5) vs L (19.9)
1.06 (0.76-1.48)
continuous covariates, first 2
years of follow up excluded
associated with low vitamin C:
3.76 (1.63-8.71)
NS continuous variables
0.09 adj for serum cholesterol
continuous covariates, first 2
years of follow up excluded
continuous covariates, first 2
years of follow up excluded:
8.34 (1.01-68.7)
3.07 (0.55-17.3)
NS agressive cases only (259)
0.64 (0.38-1.07) trend: 0.11
agressive cases current/exsmokers
0.51 (0.26-0.98)