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Observational epidemiological surveys (WG 3) page 26
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Table 13: Lycopene and cancers. Recent prospective studies based on dietary intake (µg/day)
Cancer sites Authors and
year
Lung Knekt et al.,
1999
Breast Zhang et al.,
1999
Country
Design
Finland
138/4545 (25)
USA
2697/83234 (18 years)
OR (CI) Trend Remarks
H (not defined) vs L (not defined)
OR: 1.00 (0.67-1.50)
H (12688) vs L (1520)
pre-menop OR 1.10 (0.87-1.38)
post-menop OR 1.02 (0.88-1.18)
Table 14: Lycopene and cancers. Recent prospective studies based on blood levels (µM/l)
Cancer sites Authors and
year
Lung Comstock et
al., 1997
Breast Dorgan et al.,
1998
Prostate Gann et al.,
1999
Country
Design
USA
cohort of blood donnors (8)
cases 258; selection of
matched controls 515
USA
cohort of blood donnors (9,5)
cases 105; selection of
matched controls 203
USA
Physician’s Health Study
cases 578; matched controls
1294
0.77 smokers (90) mean intake (734): OR:
1.26 (0.81-1.96)
non-smokers (28) mean intake 701;
OR: 0.46 (0.16-1.33)
0.34
0.97
OR (CI) Trend Remarks
(H vs L, not defined) 1.01
H (0.51-1.75) vs L (≤0.22)
0.5 (0.2-1.2)
H (cut off point:1.08) vs L
(0.487)
0.75 (0.54-1.06)
0.99
0.97 non smokers: (86) 0.4 (0.2-1.1) trend:
0.06
restricted to 60 cases appearing after 2
years:0.4 (0.1-1.1) trend 0.02
0.12 agressive cases only (259)
0.56 (0.34-0.92) trend: 0.05