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Observational epidemiological surveys (WG 3) page 34
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Table 19: Vitamin C and cancers. Recent case control studies on dietary intake
Cancer sites Authors and
Country
year
Design
Salivary gland Horn-Ross et al.,
USA
1997
cases: 133
controls: 184
Oesophagus Terry et al.,
Sweden
2000 cases:185 adenocarc.;
165:squamous cell carc.;.
controls: 815
Stomach Ji et al., 1998 China
cases: 1124
controls: 1451
Kaaks et al., 1998 Belgium
cases: 301
Ekström et al.,
2000
Lung De Stefani
et al., 1999
Colon,
Rectum
La Vecchia et al.,
1997
Breast Negri et al.,
1996-a
Ronco et al.,
1999
Bohlke et al.,
1999
control: 2851
Sweden
cases: 567 controls: 542
Uruguay
cases : 541 controls :
540
Italy
cases: 1953
controls: 4154
Italy
cases: 2569
controls: 2588
Uruguay
cases: 400 controls 405
Greece
cases:820 controls: 1548
OR Trend Remarks
H (>200mg/day)
vs L (≤100mg/day)
0.40 (0.22-0.70)
H (>88mg/day)
vs L (≤29mg/day)
0.6 (0.4-1.0) for squamous cell
carc., NS others
M: (H≥ 86.1) vs L ≤48.7)
0.5 (0.3-0.7)
F: (H≥77.3 vs L ≤46.8):
0.7 (0.5-1.1)
H vs L (not defined)
0.43
P