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Observational epidemiological surveys (WG 3) page 30
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Table 16: Carotenoids and cancers. Recent case-control studies based on tissue levels
Cancer sites Authors and
year
Colorectal polyps Shikany et al.,
1997
Breast van’t Veer et
al., 1996
Zhang et al.,
1997
Cervix dysplasia Nagata et al.,
1999
Country
Design
USA
cases: 472
controls: 502
5 European countries
post menopause
cases: 347
controls: 374
USA
cases: 46 controls: 63
Japan
cases : 156 controls : 156
OR (CI) Trend Remarks
β-carotene in plasma (µmol/L)
H(>0.486) vs L (median, not defined)
vs L (< median):
OR: 0,30 (0,11-0,85)
α−carotene in plasma (µmol/L)
H (0.256) vs L(0.095)
0.16 (0.04-0.62)
0.89 all other carotenoids NS after
adjustment on fruit and vegetables
0.31 Euramic study
no interaction
no effect of composite antioxidant
score
- different batches collected 1 year
apart
no correlation with intake
0.01 β-carotene (2.1vs 0.6) OR 0.65
(0.22-1.92) trend NS