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Table 41 Vitamin E and cataract
Observational epidemiological surveys (WG 3) page 73
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Authors, year and number of subjects Odds ratio and CI Comments
Knekt et al., 1992 (n = 141)
advanced cataract
case control matched for age, sex and
serum vit. E above and under 20 µmol/L; 0.53 (0.24 - 1.1) municipality.
Vitale et al., 1994 (n = 671)
advanced cataract
plasma vit. E > 29.7 vs < 18.6 µmol/L; 0.52 (0.27 - 0.99)
Jacques and Chylak, 1991 (n = 112)
posterior subcapsular cataract
plasma vit. E > 35 vs < 21 µmol/L; 0.33 (0.03 - 4.13)
early cataract
plasma vit. E > 35 vs < 21 µmol/L; 0.83 (0.20 - 3.40)
cortical cataract
plasma vit. E > 35 vs < 21 µmol/L; 0.84 (0.20 - 3.60)
Leske et al., 1998 (n = 764) Nuclear opacification
group with higher plasma vit. E.; 0.58 (0.36 - 0.94)
Robertson et al., 1989 (n = 304) advanced cataract
no supplement vs intake > 400 IU/d; 0.44 (0.24 - 0.77)
Jacques and Chylak, 1991 (n = 112) higher (> 35.7 mg/d) vs lower vitamin E intake (< 8.4 mg/d)
0.45 (0.12 - 1.79); ns
Leske et al., 1991 (n = 1380)
cortical cataract 0.59 (0.36 - 0.97)
highest quintile vs lowest one.
mixed cataract 0.58 (0.37 - 0.93)
highest quintile vs lowest one.
Mares-Perlman et al., 1994, (n = 1980)
nuclear cataract
use of vitamin E supplements; 0.9 (0.6 - 1.5)
cortical cataract
1.2 (0.6 - 2.3)
Hankinson et al., 1992 (n = 50 828)
higher (> 210 mg/d) vs lower vitamin E intake (< 3.3 mg/d) Women after adjustment for confounders:
0.96 (0.72 - 1.29)
age, diabetes,smoking and energy intake)
Leske et al., 1998 (n = 764)
longitudinal study; nutritional data and yearly followup
visits
Nuclear opacification 0.43 (0.19 - 0.99)
group using vit. E supplement.
Teikari et al., 1998 (n = 28 934)
advanced cataract
Vit. E supplementation vs placebo; male
(50 - 69 years); intervention followed for 5 to 8 years 0.91 (0.74 - 1.11)
smokers;
Lyle et al., 1999a (n=1349)
high intake (28.3mg/kcal) vs low 3.7)
hypertension: 0.4 (0.2-1.1) trend 0.02
Beaver Dam Eye Study
0.8 (0.4-1.4) trend 0.08
Lyle et al., 1999b (n=400)
high plasma concentration (5.6mmol/mmol cholesterol) vs low
Beaver Dam Eye Study
(3.2); 0.5 (0.2-1.1) trend 0.07