Table of Contents - WOC 2012

WOC2012 Abstract Book
Free Paper: Oncology
Fri 17 Feb 8:30 - 10:00 Conference Room B4
FP-ONC-FR 73 (1)
Misdiagnosis of Retinoblastoma in a Large Case Series from a
Tertiary Care Centre in India
Chawla Bhavna (1) , Sen Seema (1) , Kashyap Seema (1) , Pushker Neelam (1) ,
Sharma Sanjay (1)
1. All India Institute of Medical Sciences
Objective: To report the incidence of misdiagnosis of Retinoblastoma (Rb) in a
large case series and to describe the clinicopathological features of cases that
were misdiagnosed.
Methods: Patients who presented to the Rb clinic of our centre between 2009
- 2011 and underwent enucleation were retrospectively reviewed with respect
to histopathologic findings in enucleated eyes.
Results: A total of 140 eyes with a diagnosis of Rb based on clinical evaluation
and imaging were enucleated during the study period. Of these, the diagnosis
of Rb was confirmed on histopathology in 137 (97.9%) eyes. Three (2.1 %) eyes
had histopathological diagnosis other than Rb. These included granulomatous
endophthalmitis in Case 1, poorly differentiated malignant tumor with positivity
for glial fibrillary acidic protein(GFAP) in Case 2, and Coats› disease in Case
3. The accuracy of detecting Rb by clinical examination and use of imaging
modalities like B-scan ultrasonography, CT scan and MRI was 97.9%.
Conclusion: A good clinical acumen combined with appropriate imaging
modalities can accurately diagnose retinoblastoma in the vast majority of
cases. Misdiagnosis is very rare, but must be kept in mind to be prepared for
histopathological surprises.
FP-ONC-FR 73 (2)
Retinoblastoma; A Report from a Referral Centre in Iran: 1979 - 2007.
Ghassemi Fariba (1) , Chams Hormoz (1) , Sabour Siamak (2) ,
Karkhaneh Reza (1)
1. Tehran University of Medical Sciences, Farabi Hospital
2. Shahid Beheshti University of Medical Sciences, Faculty of Health
Background: Retinoblastoma (RB) is a relatively common childhood tumour.
This report aims to present the results of clinical characteristics, treatments
and the outcomes of the treated retinoblastoma patients from the main
ophthalmology referral centre in Iran.
Methods: A retrospective study was carried out on retinoblastoma cases
treated in Farabi Hospital since 1979 to 2007. The variables analyzed were age,
sex, affected eyes, time of the diagnosis, treatment modalities, pathological
findings and the survival.
Results: We analyzed 557 cases with a mean age of 32.2 months (Standard
Deviation = 22). There was a male predominance (60%). There were 380
unilateral cases (68.6%). Enucleation was performed in 65.6% of the patients.
Nearly 82.4% of the eyes were in stage Va and Vb Reese-Ellsworth or in a
very advanced condition. Of the enucleated cases, 43.2% of the eyes have
had undifferentiated types of tumours. Disease free survival was 68.5% in this
study (by a mean follow up of 61.9 months).
Conclusions: Given the advanced stages of disease in the majority of patients
at the time of diagnosis, the enucleation ratio of our retinoblastoma patients
is higher than other countries. In this study, iris and orbital involvement were
significantly associated with the death.
108
FP-ONC-FR 73 (3)
Electroretinographic Results in Retinoblastoma Survivors: Impact of
Tumor Size, Location and Modality of Treatment
El Gohary Amira (1) , Said Azza (2) , Ziko Othman (2)
1. Faculty of Medicine, Cairo University
2. Faculty of Medicine, Ain Shams University
Purpose: To describe the effects of different modalities of treatment of
retinoblastoma on retinal function using both flash and pattern
electroretinographies (FERG and PERG) with correlation to tumor size and
location.
Methods: The study included 75 eyes of 62 children treated successfully from
retinoblastoma by different treatment modalities in Ophthalmology
department, Ain Shams University from January 1999 to December 2003. The
retinoblastoma eyes were divided into six study groups according to treatment
modality, size and location. Evaluation of retinal function was started on March
2008 till May 2009 using FERG and PERG guided by International Society
for Clinical Electrophysiology of Vision (ISCEV) standardized basic protocols.
Results: A statistically significant increase in mean implicit times and amplitudes
of a-and b-waves in eyes with tumors treated by external beam radiotherapy
compared to chemotherapy.
Conclusion: FERG and PERG provide objective assessment of retinal and
optic nerve function in successfully treated retinoblastoma patients. Subnormal
ERG responses were correlated to large tumor size and retinal toxic effects of
the chemotherapeutic regimens with dysfunction of the photoreceptor layer.
Keywords: Retinoblastoma, Electroretinograph, Intravenous chemotherapy,
External beam radiotherapy.
FP-ONC-FR 73 (4)
Transpupillary Thermotherapy in Local Consolidation of Large
Retinoblastomas
Palanivelu Mahesh Shanmugam (1) , Ramanjulu Rajesh (1) , Kumar Madhu (1)
1. Sankara Eye Care Institutions
Objective: Transpupillary thermotherapy (TTT) is ideally used as primary
therapy or as sequential local therapy in treating retinoblastomas