Table of Contents - WOC 2012

FP-RET-TH 55 (5)
Correlation of Spectral Domain Optical Coherence Tomography (SD
OCT) Features and Fundus Fluorescein Angiography / Indocyanine
Green Angiography (FFA/ICG) Features of Choroidal Neovascular
Membranes (CNV) in Age-Related Macular Degeneration (AMD)
Mathew Raeba (1) , Sivaprasad Sobha (1)
1. Laser and Retinal Research Unit, King›s College Hospital
Purpose: To study the correlation between the morphologic features on SD
OCT and the angiographic patterns of CNV in AMD.
Methods: A retrospective analysis of the features on OCT and FFA/ICG of 100
eyes of patients, attending the AMD clinic of King›s College Hospital, London
was done. All the patients underwent visual acuity measurement, dilated
fundoscopy, SD OCT scans of the macular area and baseline angiography
with FFA +/-ICG. The morphologic patterns on OCT were correlated with the
angiographic features.
Results: The angiographic classifications of CNV were graded as predominantly
classic, minimally classic, occult, retinal angiomatous proliferation (RAP) and
polypoidal vasculopathy (PCV). Classic CNV were identified as areas of
thickening involving or above the retinal pigment epithelium (RPE). Occult
membranes were identified as hyper reflective areas below the RPE, frequently
associated with a pigment epithelial detachment. RAP could be identified by the
presence of retinochoroidal anastomosis. Polyps could be seen as prominent
hyper reflective spikes arising from areas deeper to the RPE. There were very
few atypical cases.
Conclusions: Advanced OCT technology helps to identify the various sub types
of CNV hitherto diagnosed by angiography. Good correlation is achieved
between OCT morphology and angiography.
FP-RET-TH 55 (6)
Investigate Color Vision Disturbance in Patients Who Are Taking
Dioxin
Davari Mohammad Hossein (1) , Yaghoobi Gholamhossein (1) , Kazemi Toba (1) ,
Gheytasi Hoda (1) , Afrazandeh Hanieh (1)
1. Birjand University of Medical Sciences
Background: Digoxin is a drug that commonly used in treatment of heart failure
and is cause to various complications of color vision.
Method: Case group of 59 patients with heart failure were at least a year taking
oral digoxin. The control group was chosen among patients who have no
cardiac disease referred to hospital or patients› relatives that have no use
digoxin. Control group matched of age and gender with control group. Both
groups were evaluated with Ishihara color test for any color vision disturbance.
Venous blood samples were obtained for measurement of serum digoxin level.
Then information using SPSS software and statistical T-test and Fisher exact
test was encoded with a significance level of ±=0.05.
Result: The mean age and gender groups showed no significant difference.
Relative frequency of color vision disturbance was obtained in the case group
6.8 % and in the control group 1.7 %. But this difference was not statistically
significant. Frequency resolution color vision disturbance on age and gender
showed no significant difference. Serum digitalis concentration was abnormal
in 5.1 % of patients but this difference was not statistically significant.
Conclusion: In our study there was no significant relationship between serum
digoxin level and color vision disturbance.
WOC2012 Abstract Book
FP-RET-TH 55 (7)
Advantage of Three Dimensional Spectral Domain Optical Coherence
Tomography Over Conventional Two Dimensional OCT Scans in
Cases of Choroidal Neovasculalization
Saeed Shahzad (1) , Ishaq Mazhar (2) , Dar Asad Jamal (3) , Humayun Sadia (4)
1. Armed Forces Institute of Ophthalmology
2. Armed Forces Institute of Ophthalmology
3. Armed Forces Institute of Ophthalmology
4. Combined Military Hospital
Objective: Compare three dimensional (3D) Optical Coherence Tomograms
(OCT) of cases of choroidal neovascularization (CNV) with conventional two
dimensional (2D) OCT. The aim is to assess the advantage of 3D OCT in terms
of morphology, clinical progression / response to treatment and as an aid in
vitreoretinal surgery in cases of CNV.
Method: Both 2D and 3D OCT of patients with CNV were taken and compared
in terms of detailed morphology, assessment of clinical progression and
response to treatment. Scans were taken pre and post treatment for comparison
to assess the response to treatment.
Result: Although 2D OCT depicts the pathology in neurosensory retina more
accurately with easier interpretation, but 3D OCT has clear advantage in
diagnosis of retinal disorders involving the retinal pigment epithelium (RPE)
like CNV. It depicts the changes in RPE more comprehensively. In addition
post-treatment changes in retinal morphology in cases of CNV are more
accurately assessed.
Conclusion: Exact retinal morphology and pre and post treatment changes in
cases of CNV are more accurately assessed with 3D OCT as compared to 2D
scans. In addition, 3D scans can be utilized as an aid in planning vitreoretinal
surgery.
FP-RET-TH 55 (8)
Reversal of Reactive Gliosis Promotes De Novo Vascular
Remodelling and Rescues the Neurosensory Retina During Ischemic
Retinal Vasculopathies
DeNiro Michael (1) , Al-Mohanna Falah (2) , Al-Mohanna Futwan (2)
1. King Khaled Eye Specialist Hospital
2. King Faisal Specialist Hospital and Research Centre
Objective: Retinal neovascularization [NV] is a major cause of blindness in
ischemic retinopathies. Previous investigations have indicated that ischemia
upregulates GFAP, PDGF-B, and iNOS expression. GFAP overexpression is a
hallmark of reactive gliosis [RG], a pathophysiological feature of retinal damage.
Furthermore, data have indicated that PDGF-B was implicated in proliferative
retinopathies; while iNOS upregulation promotes inhibition of angiogenesis.
We evaluated the efficacy of YC-1, a HIF-1 inhibitor, in modulating PDGF-B
and iNOS expression and reversing RG and NV.
Method: An array of assays to evaluate the effects of YC-1 on RG and NV; in
vitro and in vivo.
Result: YC-1 reduced the hypoxia/ischemia-induced expression of GFAP,
PDGF-B, and iNOS message and protein levels, in vitro and in vivo. Furthermore,
YC-1 reduced the neovascular sprouts length and number, inhibited ischemic
pathologic neovascular response, promoted revascularization and repaired the
central retina.
Conclusion: YC-1 reversed RG and rescued the neurosensory retina during
ischemic retinopathy through impairing the expression of GFAP in Muller cells.
This is the first investigation that delves into the reversal of RG and the rescue
of the neurosensory retina during ischemic retinal vasculopathies. YC-1 may
exert pleiotropic promising therapeutic effects in the treatment of retinal and
neuronal pathologies.
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