Table of Contents - WOC 2012

WOC2012 Abstract Book
PO-REF-41
Femtosecond laser flap characteristics with 60o and 130o side cut
angle in myopic laser in situ keratomileusis
Mutmainah Nina (1,2,3) , Hutauruk Johan (1,2,3)
1. Ophthalmology Department, Cipto Mangunkusumo Hospital
2. Faculty of Medicine, University of Indonesia
3. Jakarta Eye Center
Purpose: To compare characteristics of 60o and 130o side cut angle
femtosecond flaps in myopic laser in situ keratomileusis.
Methods: Corneal flap was created in both eyes of 20 subjects using
femtosecond laser (IntraLase) with side cut angle 60o or 130o for each eye
(randomized). On day 1, 7, and 30, visual acuity and flap gutter were examined,
visual analog scale (VAS) questionnaire for ocular discomfort were collected.
Corneal topography was scanned on day 7 and 30. Difference between the
smallest-largest corneal power (D) in ring 7 on tangential map (? ring 7) was
observed.
Results: Both group achieved optimal best-corrected visual acuity (p>0.05). On
day 7 and 30, ? ring 7 value of group 130o was slightly lower than group 60o,
but not statistically significant (p>0.05). Proportion of less apparent corneal
gutter in group 60o was slightly higher than group 130o on day 1 and 7 without
statistical difference (p>0.05). No statistical difference was found in VAS value
of both groups in each follow up (p>0.05).
Conclusions: In this study, no superiority was found in 130o side cut angle
femtosecond flaps compared with 60o, in terms of visual outcomes, flap
surface homogenity, flap gutter, and ocular comfort.
Retina
PO-RET-01
RETINAL VENOUS OCCLUSIVE DISEASES IN RELATION TO RISK
FACTORS
Malaravan Muthusamy (1) , Wariyapola Dushyanda (1)
1. Department of Ophthalmology, General Hospital
PURPOSE: To investigate risk factors for Retinal vein occlusion (RVO).
DESIGN: Retrospective case - control study.
Methods: Consecutive patients with RVO examined from August 2007 to
August 2008 were compared with an historical gender and age - matched
control group of patients with ocular problems other than RVO from the same
referral practice (Case : Control=1:2). Risk factors for RVO were evaluated.
Results: The 55 patients in the RVO group, 25 males and 30 females, had a
mean age of 62.527 years (±7.769 years). RVO was associated with
hypertension (p=0.003), diabetes mellitus (p=0.003), Ischemic heart disease
(p=0.003), Aspirin use (p=0.003) and Clopidogrel use (p=0.003). RVO was not
associated with hypercholesterolemia (p=0.874) and Glaucoma (p=0.525).
Conclusions: We found many of the same risk factors previously identified for
RVO by other studies except glaucoma and hypercholesterolemia, but we
identified both Aspirin & Clopidogrel use to be risk factors for RVO. Although
these findings suggest the vasculopathic and prothrombotic risks in some
patients may not be addressed adequately by antithrombotic therapy. The
pathogenesis of RVO may be more complicated than just the development of
a primary thrombus with in the vein.
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PO-RET-02
Association of diabetic retinopathy with suboptimal glycemic, blood
pressure and lipid control:
Raman Rajiv (1) , Gupta Aditi (1) , Kulothungan Vaitheeswaran (1) , Sharma Tarun
(1)
1. Sankara Nethralaya
Purpose: To assess the rate of achieving and factors associated with all
glycemic, blood pressure and lipid control among people with type 2 diabetes
and to elucidate their influence on DR.
Methods: The study population consisted of 1414 subjects with Type 2
diabetes. Optimal control of HbA1c and BP was described based on revised
recommendations of American Diabetes Association. DR was diagnosed
based on the Modified ETDRS scales.
Results: 13.6% subjects reached the combined target levels for all metabolic
parameters. HbA1c level > 9% (very poor control) was present in 28.4% and
55.3% of subjects without and with DR, respectively. Very poor SBP (>170 mm
Hg) control was present in 5.6% and 8.2% of subjects without and with DR,
respectively. Those with combination of suboptimal glycemic and SBP control,
glycemic and DBP control , glycemic, SBP and LDL control, and glycemic, DBP
and LDL control were more likely to have DR when compared to subjects with
optimal control of respective combinations. The factors associated with DR
in this group were younger age, male, presence of anemia and presence of
microalbuminuria.
Conclusion: We report high prevalence of suboptimal glycemic , BP and lipid
control among subjects with diabetes.
PO-RET-03
Role of the renin-angiotensin-aldosterone system and VEGF-A in the
patogenesis of diabetic retinopathy.
Lipatov Dmitry (1) , Bautina Ylia (1) , Kuzmin Anatoly (1) , Goncharov Nikolay (1) ,
Shestakova Marina (1)
1. Reserch Endocrinology Center
Background: the study aim was to evaluate the angiotensin II (ATII) and
vascular endothelial growth factor A (VEGF-A) value and the direct renin activity
(DRA) in the aqueous humor (AH) from patients with diabetic retinopathy (DR).
Materials: AH samples were obtained from diabetic eyes with various stages of
DR and non-diabetic eyes operated due to cataract and neovascular glaucoma
(NG). Protease inhibitor was added to samples and they were immediately
frozen and stored at -50°C until analysis performing.
Results: The level of the VEGF-A enhanced accordingly the severity of the DR.
There was the VEGF-A value 59,6 pg/ml in AH in non-proliferative DR (n=12)
and 111,5 pg/ml in proliferative DR (n=7). Non-diabetics (n=5) had the
VEGF-A about 42 pg/ml in AH. The ATII value in the AH was 30,2 pg/ml in
non-proliferative DR (n=18) and 30,7 pg/ml in proliferative DR (n=9). In nondiabetics
(n=5) ATII level in the AH was 32,9 pg/ml.
Conclusion: There wasn›t observed any correlation between DR severity and
ATII value in the AH. No relationship between VEGF-A value and ATII in the
AH was found in groups of patients. The DRA wasn›t determined in any AH
samples.