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Table of Contents - WOC 2012

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<strong>WOC</strong><strong>2012</strong> Abstract Book<br />

PO-GLA-55<br />

Tear Film Osmolarity Changes and Intraocular Pressure Control<br />

Using Preservative-free Tafluprost<br />

Januleviciene Ingrida (1) , Derkac Irmante (1) , Braziene Kristina K, Grybauskiene<br />

Lina<br />

1. Eye Clinic <strong>of</strong> Kaunas Medical Academy <strong>of</strong> Lithuanian University <strong>of</strong> Health<br />

Sciences<br />

Purpose: To evaluate tear osmolarity changes and IOP control using<br />

preservative-free Tafluprost. Design: Observer masked prospective 12 weeks<br />

pilot study.<br />

Methods: 30 open angle glaucoma patients (60 eyes), aged 64.1 (SD 14.1)<br />

years, mean time on glaucoma medication 3.6 (SD 3.2) years showing<br />

abnormal values <strong>of</strong> tear osmolarity and/or corneal fluorescein staining and/or<br />

tear film break-up time (BUT) and/or subjective discomfort while treated with<br />

Benzalkonium chloride (BAK) containing prostaglandine analogue Latanoprost<br />

were switched to preservative-free Tafluprost. Tear osmolarity (TearLabTM<br />

Osmolarity System), BUT, corneal fluorescein staining, IOP were measured at<br />

Latanoprost baseline and after 2, 6, 12 weeks <strong>of</strong> Tafluprost treatment.<br />

Results: Tear osmolarity decreased from 315 to 302 mOsm/L using Tafluprost<br />

(p0.05). BUT increased statistically<br />

significantly from 3.7±1.1 s to 6.5±1.5 s (p

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