Table of Contents - WOC 2012

WOC2012 Abstract Book
FP-IMG-SU 317 (2)
Circadian and Orthostatic Influences on Cystoid Macular Edema
Morphology
Kiss Christopher (1) , Munk Marion (1) , Sulzbacher Florian (1) , Huf Wolfgang (2) ,
Schmidt-Erfurth Ursula (1)
1. Department of Ophthalmology and Optometry, Medical University of Vienna
2. Department of Statistics and Probability Theory, University of Technology
Purpose: To identify the influence of orthostatic and diurnal changes on the
morphology of cystoid macular edema (CME).
Methods: Sixteen patients (18 eyes) diagnosed with CME were examined
using the Heidelberg Engineering SPECTRALIS HD-OCT in 4-hour-intervals
between 8am and 8pm. Examination of the exact same retinal area was
ensured using Heidelberg›s proprietary follow-up function. Additionally, at 4
pm an orthostatic test was performed and monitored using the Zeiss Cirrus
HD-OCT.
Results: Changing from a reclined into an upright position led to an immediate,
significant decrease central retinal thickness (CRT) from 496±37 µm to 412±43
µm, i.e. 20% within the first 20 seconds after the position change. The diurnal
pattern showed a small but statistically significant decrease of CRT. The total
variation was 3.5% with the highest CRT in the morning and the lowest in the
evening.
Conclusions: Intraretinal fluid volume in CME appears to be linked to orthostatic
changes following position changes of the patient. CRT decreases significantly
within seconds after moving from a reclined to an upright position. Furthermore
CRT is largest in the morning hours continuously decreasing during the day,
making timing an important factor to consider when comparing retinal thickness
values during follow-up.
FP-IMG-SU 317 (3)
Development and Triamcinolone Induced Resolution of Cystic
Macular Edema in Uveitis: Correlating Morphology with Functional
Treatment Outcome
Munk Marion (1) , Bolz Matthias (1) , Sulzbacher Florian (1) , Ruckert Rene (2) , Kiss
Chistopher (1)
1. Department of Ophthalmology and Optometry, Medical University Vienna
2. Bayer Health Care AG, Global Clinical Development
Gaining insight into morphological and functional aspects of uveitis-associated
cystoid-macular-edema (CME) using high-resolution optical-coherencetomography
(HD-OCT). Twenty-eight eyes with uveitis-associated CME were
examined before and after intravitreal-triamcinolone-injection (IVTA) for 3
months. Retinal morphological changes including cyst size, distribution and
development, layer-integrity and subretinal-detachment (SRD) were evaluated
using HD-OCT. Findings were correlated to functional aspects, such as bestcorrected-visual-acuity
(BCVA). Uveitis-associated CME –in contrast to CME of
other origin - showed a characteristic denture-like appearance: Following IVTA,
first the big foveal cysts diminished, followed by the small parafoveally located
incisor-like-organized INL cysts. Fifteen of 28 eyes with CME showed SRD
before treatment initiation which resolution lagged behind cyst disappearance.
Within a CME-relapse, INL cysts first developed, followed by typical big
centrally-located cysts, whereas no subject showed new- or reappearance of
SRD within the observation period. Presence of initial SRD was a predictor for
a relapse free clinical course, whereas 75% of subjects without SRD showed
a cyst relapse. Uveitis-associated CME presents characteristic morphologic
alteration discernible from CME of other origin. Different morphologic patterns
in uveitis-associated CME may represent different stages in the progression of
uveitis-associated CME and initial morphologic appearance can be linked to
the clinical prognosis after treatment.
300
FP-IMG-SU 317 (4)
The Utility of the Transversal OCT Scans in Central Serous
Chorioretinopathy
Poposki Vladimir (1, 2) , Vilaplana Daniel (1) , Poposka Daniela (3) , Alarcon Isaac
(1) (1)
, Castilla Miguel
1. Hospital del Mar-Esperanza, IMAS
2. Institut Catala de Retina
3. Hospital Municipal de Badalona
Purpose: In central serous chorioretinopathy (CSC), we evaluated the optical
coherence tomography (OCT) images of the retinal pigment epithelium (RPE)
obtained by scanning in a transversal direction (parallel to the retinal surface),
and compared them, firstly, with the morphological findings in the unaffected
eyes and secondly, with the leakage points on fluorescein angiography (FA).
Methods: In the prospective study 42 eyes of 21 patients with unilateral acute
CSC were examined with OCT Cirrus-HD (Macular Cube-Advanced
Visualization-RPE Slice). CSC was confirmed in 21 eyes (Group A) and the
contralateral 21 healthy eyes formed the Group B. FA was obtained in all
patients. Central macular thickness and the major demographics were also
recorded.
Results: Transverse OCT images showed irregular lesions in RPE: Group A:
100%; Group B: 9, 5% (2/21). The analyzed results agreed in 85, 7% (18/21)
with the fluorescein dye leakage location on FA.
Conclusions: In eyes with acute CSC, in contrast with conventional longitudinal
OCT scans, the extent of the disease could be visualized more accurately by
providing transversal slice at RPE. A good correlation between the transversal
OCT findings and the FA images was demonstrated by typical hyporeflective
morphologic changes at the point of dye leakage.
FP-IMG-SU 317 (5)
Optimisation of RIALAB, an Automated Drusen-Quantifying
Software, in Analysing Drusen Distribution in Age-Related Macular
Degeneration
Ong Beng Beng (1) , Lee Wai Ping (2) , Lee Noah (3) , Pearce Elizabeth (2) , Smith
Theodore (4) , Chong Victor (1,5)
1. Oxford University
2. Oxford Radcliffe Hospitals NHS Trust
3. Heffner Biomedical Imaging Laboratory
4. Columbia University
5. Oxford Eye Hospital
Purpose: Traditionally drusen in age-related macular degeneration (AMD) is
difficult to quantify reliably. In this pilot study, we demonstrate application of
an automated drusen segmentation algorithm in delineating and quantifying
drusen distribution from retinal photographs. To improve throughout to study
large numbers of images, a cross-validation study was performed to optimize
algorithm parameters.
Methods: 123 images with drusen were selected from two epidemiological
studies and run through various combinations of RIALAB algorithm parameters
based on possible drusen phenotype configurations, such as distribution,
hardness, and presence of pebble. The resulting output of delineated drusen
was cross-checked by an observer to determine the most appropriate setting.
Results: 99 images (80.5%) had the parameter Few Outer as the best setting
(p