Table of Contents - WOC 2012

WOC2012 Abstract Book
FP-IMG-SA 243 (3)
Must know› About Magnetic Resonance Imaging for an
Ophthalmologist
Aggarwal Ekta (1) , Noronha Veena (2)
1. Vasan Eye Care Hospitals
2. VRR Scan
Purpose: What an ophthalmologist should know about Magnetic Resonance
Imaging. Methods: Magnetic Resonance Imaging is an indispensable
investigative tool in the evaluation of orbital and neuro-ophthalmic lesions.
Its superior soft tissue contrast multiplanar capabilities and lack of ionizing
radiations gives it an edge over Computed Tomography (CT). Besides basic
technicalities, this paper shall address the imaging anatomy of the orbital
and adjacent structures. The key MRI features of common cranio-orbital
pathologies shall also be mentioned briefly. Result and Conclusion:
The basic interpretation of MRI imaging for an ophthalmologist, especially the
oculoplastics surgeon and neuro-ophthalomologist, shall be made simpler
through this presentation.
FP-IMG-SA 243 (4)
DiOCTA : A Device Independent OCT Analysis
Lorenz Birgit (1) , Zahn Steffen (1) , Pilch Mattheus (1) , Ehnes Alexander (1) ,
Stieger Knut (1)
1. Department of Ophthalmology, Justus-Liebig-University Giessen
Aim: Current optical coherence tomography (OCT) technology generates vast
amounts of data for disease identification and clinical studies of new
therapeutics. Differences in the software from devices of distinct generations
and companies complicate the analysis in multicenter studies. The aim of this
project is to generate a software application for raw data analysis from different
OCT devices. Method: Raw Data from currently available OCT devices
can be imported into the new analysis software and are processed in a three
component operation, including automated layer segmentation, automated
structure recognition and a disease advisory system based on Bayesian
model systems. Results: The automated layer segmentation allows
the segmentation of 11 intra-retinal layers and can be adjusted in diseased
retinal images depending on the severity of layer reduction. Automated
structure recognition can detect all vessels with their respective lumen and
recognizes small dense particles and fluid containing compounds in a C-scan.
The disease advisory system is currently set up for retinal degenerative
disorders, in particular for LCA and RP pathology. Discussion: The device
independent software can be applied in multicenter studies to analyze the
natural history of retinal pathologies over time and can evaluate the treatment
benefit of new therapeutic applications.
FP-IMG-SA 243 (5)
Adaptive Optics-Like Quality SLO-OCT Fundus Imaging Using
Compact Ultra High Resolution Confocal Microscopy and Ultra High
Speed SD OCT
Rosen Richard (1,2)
1. New York Eye and Ear Infirmary
2. New York Medical College
PURPOSE: To develop an adaptive optics-like quality imaging system for
clinical macular diagnosis,using combined Ultra High Resolution Confocal
Microscopy and Ultra High Speed SD OCT. METHODS: Clinical subjects
diagnosed with retinal disease were imaged using an enhanced commercial
ultra high resolution confocal microscope/ ultra high speed SD OCT capable
of magnifications revealing the photoreceptor matrix, nerve fiber layer fabric,
and deep capillary beds . Clinical pathologic correlation was assessed on all
images using conventional SD OCT/SLO imaging and fundus photography.
RESULTS: Eyes of 20 patients with diabetic retinopathy, cystoid maculopathy,
vascular occlusive disease, serous retinopathy, and macular degeneration
were studied. Compared to current commercial OCT and SLO imaging devices
the system was able to reveal cellular details and fine structure previously
only available in larger adaptive optics systems which are cumbersome for
the clinical environment. CONCLUSION: This system demonstrates the
potential accessibility to microstructural imaging beyond current commercial
standards to a level approaching adaptive optics resolution without its complex
optical architecture. Its ability to detect subtle structural abnormalities may
prove exceptionally valuable for detectionof preclinical macular disease as
pharmacological therapies focus on more subtle chronic changes.
236
FP-IMG-SA 243 (6)
Does Ultrasound Bio-Microscopy Have a Role in the Diagnosis of
Temporal Arteritis?
Mansour Magdi (1) , Deschenes Jean (2) , Khouqeer Zohair (1) , Al-Habbab
Zainab (1)
1. Saad Specialist Hospital
2. Royal Victoria Hospital
Objective: To evaluate the role of ultrasound biomicroscope (UBM) in the
diagnosis of temporal arteritis. Method: Prospective case study, of twenty-six
consecutive patients with clinical diagnosis of temporal arteritis was enrolled in
this study. All patients were submitted to UBM before temporal artery biopsy.
On UBM we searched for the presence of a hypoechoic effect surrounding the
walls of the temporal arteries (halo sign), as well as an intra-arterial middle
reflexive filling (intra-arterial filling affect). Results: The halo sign and the
intra-arterial filling were simultaneously found in 5 (62.5%) of 8 patients with
biopsy-proven temporal arteritis. However, only 6 (30%) of 18 patients with a
negative biopsy presented both features simultaneously. On the other hand,
the absence of these two parameters on the UBM of a patient with clinical
suspicion of temporal arteritis strongly suggests that the temporal artery biopsy
will be negative (negative predictive value=100%). Conclusion: This study
suggests that the ultrasound biomicroscopy is a useful exam in predicting
a negative result of the temporal artery biopsy in patients with suspicion of
temporal arteritis.
FP-IMG-SA 243 (7)
Spectral Domain Anterior Segment Optical Coherence Tomography
in Microbial Keratitis
Soliman Wael (1) , Fathalla Ahmed (1) , El-Sebaity Dalia M (1) ,
Al-Hussaini Ashraf K (1)
1. Ophthalmology Deparment, Assiut University Hospitals, Assiut University
Purpose: To investigate the spectral domain anterior segment optical
coherence tomography (SDAS-OCT) characteristics of microbial keratitis
(fungal and bacterial keratitis). Methods: Twenty eyes of 20 patients with
proved fungal and bacterial microbial keratitis, at different stages, underwent
SDAS-OCT. Results: We examined 20 eyes of 20 patients. Eight
eyes presented with proved bacterial keratitis and 12 eyes presented with
proved fungal keratitis. Twelve different SDAS-OCT presentations of fungal
and bacterial keratitis were explored in this study. These twelve presentations
are hyper-reflective stromal lesions, epithelial defects, stromal edema, hyperreflective
material (inflammatory plaque or mucous) over-lost epithelium or
over the hyper-reflective stromal lesion, hyper-reflective lesion (inflammatory
plaque attached to the endothelium), localized small stromal cystic spaces,
full thickness large cystic spaces (necrotic stroma), localized stromal thinning
with defective epithelium on top, loss of all layers of the cornea except the
Descemet›s membrane (Descematocele), hyper-reflective stromal lesion(scar)
with intact epithelium on top without stromal thinning, hyper-reflective stromal
lesion(scar) with intact epithelium on top with localised stromal thinning, and
diffuse stromal thinning with defective epithelium. Conclusions: SDAS-
OCT imaging provides a range of characteristics that can be used in the
future as an integral part in diagnosis and management of bacterial and fungal
microbial keratitis.
FP-IMG-SA 243 (8)
Optical Quality and Wavefront Aberrations in Normal, Forme Fruste,
and Manifest Keratoconus
Dhawan Shikha (1) , Shetty Rohit (2) , K Shetty Bhujang (2) , Sasikumar Rajesh (2)
1. Aditya Jyot Eye Hospital
2. Narayana Netralaya
Purpose: To evaluate optical quality and wavefront aberrations in normal,
forme fruste and manifest keratoconus. Methods: A Prospective
observational comparative study in 64 keratoconic eyes of 96 patients, 22
forme fruste keratoconic eyes of 38 patients, and 100 healthy eyes of 168 age-
and sex- matched subjects was performed. In the keratoconus group three
further groups were differentiated according to the severity of keratoconus:
mild (22 eyes), moderate (20 eyes) and severe keratoconus (22 eyes). Optical
quality measurements were performed using the Optical Quality Analysis
System (OQAS). Wavefront aberrations were measured and studied using
Tscherning Aberrometer. Results: The difference in the mean values
of the optical quality parameters between the normal and forme fruste group
(p