Table of Contents - WOC 2012

FP-ONC-FR 73 (5)
Criteria for Postoperative Chemotherapy in Children with Monocular
Retinoblastoma after Initial Enucleation
Ushakova Tatiana (1) , Pavlovskaya Alentina (2) , Polyakov Vladimir (1)
1. Institute of Pediatric Oncology and Haematology N. N. Blokhin CRC
2. N. N. Blokhin Cancer Research Center RAMS
Objective: The aim of this report is to describe histopathological findings in
children with monocular retinoblastoma after initial enucleation as indicators
for postoperative chemotherapy.
Methods: Forty three patients have undergone primary enucleation. The
median age was 28+17, 6 months at the time of enrollment. Specific risk
characteristics on histopathology reports were identified.
Results: Seventeen of forty three patients had standard- risk characteristics as
insufficiency or minimum tumor invasion choroid and prelaminar invasion
of the optic nerve. Eighteen of forty three patients had intermediate- risk
characteristics as invasion into the anterior chamber, iris, ciliari, body massive
tumor invasion choroid, intra- and retrolaminar invasion of the optic nerve.
Eight of forty three patients had high-risk characteristics as tumor invasion of
optic nerve transection and extrascleral extention.
Conclusions: Our histopathologic review of 43 series of retinoblastomas,
treated by enucleation, showed that 26 (60, 5%) in 43 had histopathologic
risk factors that currently are indicators for adjuvant chemotherapy. The latter
include intermediate and high- risk characteristics.
FP-ONC-FR 73 (6)
Outcome of Orbital Retinoblastoma Managed with Multimodal
Treatment Protocol
Fairooz PM (1) , G Honavar Santosh (1) , Javed Ali Mohammed (1) , P Reddy Vijay
Anand (1)
1. LV Prasad Eye Institute
Purpose: Orbital retinoblastoma has up to 75% mortality by conventional
therapy. We used an intensive multimodal treatment protocol in such patients.
Methods: Retrospective interventional case series of 30 consecutive patients
with orbital retinoblastoma. Intensive stepwise therapy included highdose
neoadjuvant chemotherapy (carboplatin, vincristine and etoposide),
followed by enucleation after radiological confirmation of regression of the
orbital component, external beam radiotherapy, and adjuvant chemotherapy.
Systemic metastasis was the outcome measure.
Results: Orbital retinoblastoma was primary in 16 (54%), secondary in 4 (12%),
accidental in 7 (23%), overt in 2 (7%) and microscopic in 1 (3%). Systemic
metastasis occurred in 2 of 30 (6.6%) at a mean follow-up of 35.2 months,
while 28 (93.4%) were tumor-free. Kaplan-Meier analysis showed 90% survival
at 100 months.
Conclusion: Intensive multimodal treatment of orbital retinoblastoma
dramatically improves patient Survival.
FP-ONC-FR 73 (7)
Outcome of Retinoblastoma with Vitreous Seeds
Fairooz PM (1) , G Honavar Santosh (1) , A Reddy Vijay Anand
1. LV Prasad Eye Institute
WOC2012 Abstract Book
Purpose: To analyze the outcome of retinoblastoma with vitreous seeds
managed with high-dose chemotherapy coupled with periocular chemotherapy.
Method: Retrospective interventional series of 137 consecutive eyes with
retinoblastoma with vitreous seeds managed with high-dose chemotherapy
(carboplatin +etoposide + vincristine) and periocular carboplatin over 10 years.
Tumor and vitreous seeds regression were the outcome measures.
Results: Chemotherapy cycles ranged from 6 to 12 (median 9); 63 (47%) eyes
with diffuse vitreous seeds received concurrent periocular carboplatin injections
(median 6). The mean follow-up duration was 15 months. Complete regression
of the tumor and vitreous seeds was seen in 79 (59%) at the final follow-up.
None of the patients developed systemic metastasis.
Conclusion: Protocol-based intensive management with high-dose
chemotherapy and periocular carboplatin provides for gratifying outcome in
advanced retinoblastoma with vitreous.
FP-ONC-FR 73 (8)
The First Eye Salvage Program for Retinoblastoma in Jordan
Al-Nawaiseh Ibrahim (1) , Barham Rasha (1) , Mehyar Mustafa (1)
1. King Hussien Cancer Center
Purpose: To Evaluate the outcome of Retinoblastoma treatment in Jordan
including chemotherapy, local therapy, radiotherapy and enucleation.
Methods: We performed a retrospective chart review of 115 patients (180 eyes)
diagnosed with retinoblastoma including their initial staging, management and
final outcome between March 2003 and April 2011.
Results: There were a total of 180 eyes diagnosed with Retinoblastoma
between March 2003 and April 2011: 50(43.5%) patients were unilateral,
65(56.5%) patients were bilateral. Tumor control and eye salvage were
achieved in 96 of the 180 eyes; the probability of ocular survival was 53.3%.
155 (86%) eyes received chemotherapy (adjuvant and neoadjuvant ) plus
focal therapy (Transpupillary Thermotherapy and Cryotherapy). 3(1.7%) eyes
received plaque therapy. 60(33.3%) eyes underwent enucleation , of these
60 eyes , 3(2.6%) patients underwent bilateral enucleation. 28(15.6%) eyes
received External Beam Radiotherapy. 5 patients died(4.3%).
Conclusion: Retinoblastoma management needs a multidisciplinary team
approach in a specialized centre. Still Retinoblastoma is a fatal disease if not
discovered early and treated properly.
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