Table of Contents - WOC 2012

IS-ONC-FR 113 (3)
Emerging Molecular Biology of Conjunctival Melanoma: Arrestins
and ERK Signaling, Functional and therapeutic implications
Girnita Leonard (1)
1. Karolinska Institutet
The major paradigm of melanoma biology is the hyperactivation of the RAS/
RAF/MEK/ERK signaling pathway. This pathway is normally activated
downstream of receptor tyrosine kinases, cytokines and heterotrimeric
G-protein-coupled receptors. Unlike skin melanoma, in conjunctival melanoma
BRAF and RAS are rarely mutated; instead MAPK signaling pathway is
hyper activated by other mechanisms, bypassing the need for RAS or BRAF
mutations. The aim of the present report is to highlight these mechanisms as
well as to discuss their potential as therapeutic targets.
IS-ONC-FR 113 (4)
Conjunctival Melanoma
Damato Bertil (1)
1. Royal Liverpool University Hospital
This presentation will cover the clinical features, differential diagnosis,
pathology, investigation and treatment of in situ and invasive conjunctival
melanoma. Delegates will learn how to assess patients and how to achieve
local tumour control without inducing iatrogenic tumour seeding, which is lifethreatening.
IS-ONC-FR 113 (5)
Ultra High Resolution OCT for Imaging of Ocular Surface Tumors
Karp Carol (1)
1. Bascom Palmer Eye Institute
New imaging techniques are evolving for the evaluation and management of
ocular surface tumors. This lecture will discuss exciting new methods of
evaluating and managing ocular surface tumors using ultra high resolution
ocular coherence tomography (UHR-OCT). “Optical biopsies” will be presented
along with the corresponding histopathology. The audience will learn how to
distinguish, diagnose, and monitor various tumors using the UHR-OCT.
IS-ONC-FR 113 (6)
Management of Conjunctival Lymphoma
Johnson Thomas (1)
1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Ocular adnexal lymphoid tumors can affect the orbit, conjunctiva, or eyelid.
They can occur in isolation or be part of a systemic lymphoma. Patients
diagnosed with ocular adnexal lymphoma should undergo a complete systemic
workup to evaluate for systemic disease. Treatment options for conjunctival
lymphomas may include excision, radiation therapy, monoclonal antibody
therapy, or systemic chemotherapy when associated with systemic lymphoma.
Continued follow-up of patients is important to evaluate for recurrence or later
development of extraocular lymphoma.
IS-ONC-FR 113 (7)
OSSN: The Integrated Treatment
Midena Edoardo (1)
1. University of Padova
Ocular surface squamous neoplasia (OSSN) are the most common tumors of
the conjunctiva. Their prevalence is growing because OSSN are becoming
more diffuse among young people, affected by immunodeficiency (both virally
and iatrogenically induced) and in geographic areas previously uninvolved.
The correct therapeutic approach cannot be simply related to surgery, because
surgery has high recurrence rate. Therefore any case needs to be individually
considered. Surgery and immediate reconstruction, debulking and adjuvant
chemotherapy represent the armamentarium to adequately treat OSSN.
IS-ONC-FR 113 (8)
Conjunctival Melanoma and UV Radiation
Seregard Stefan (1)
1. Department of Vitroretinal Disease, St Eriks Eye Hospital
WOC2012 Abstract Book
Cutaneous melanoma incidence is rising rapidly in the Western world and this
rise is attributed to ultraviolet radiation (UVR) exposure. In contrast, the interior
of the eye is largely protected from UVR and the incidence of uveal melanoma
is largely stable. Conjunctival melanoma is unique in that these tumours
may arise in both the setting of a mucous membrane exposed to UVR or in
conjunctiva not exposed to UVR. This makes conjunctival melanoma aptly
suited to study tumorigenesis.
Retinal Imaging
Fri 17 Feb 13:30 - 15:00 Conference Room B2
IS-IMG-FR 114 (1)
Advances in ICG angiography
Han Lim Tock (1)
1. National Healthcare Group Eye Institute, Tan Tock Seng Hospital
Combining confocal aperture, scanning laser technology and dynamic capture,
cSLO-ICGA allows imaging of the feeder vessels of choroidal neovascular
(CNV), polypoidal choroidal vasculopathy (PCV). As there is recrudescence of
photodynamic therapy for PCV, accurate lesion localization by cSLO-ICGA has
become important clinically. Using tracking laser, image co-location between
ICGA, FA and OCT is now possible. Co-located multi-modality imaging is
crucial in cases of diagnostic challenge (e.g. PCV vs. central serous chorioretinopathy,
and in PDT planning. Illustrative cases will be discussed.
IS-IMG-FR 114 (2)
Advances in Fundus Autofluoresence
Sadda SriniVas (1)
1. University of Southern California, Doheny Eye Institute
Fundus autofluoresence (FAF) imaging has become an important tool in the
diagnosis and monitoring of a variety of disorders including inherited retinal
dystrophies and age-related macular degeneration. Recent advances in FAF
imaging, such as the availability of alternative wavelengths and widefield
imaging, have further expanded the scope and importance of FAF. Peripheral
FAF abnormalities may be observed in over 2/3 of eyes with retinal disease
and may be diagnostic for certain diseases. Improved understanding of these
findings is of clinical importance.
IS-IMG-FR 114 (3)
Interpreting OCT Images: “The Fine Points”
Costa Rogerio
Abstract not available
IS-IMG-FR 114 (4)
Future OCT Technologies
Kiss Szilard (1)
1. Weill Cornell Medical College
Due to its ability to visualize ocular structures with high-resolution and high
precision, optical coherence tomography (OCT) has become an indispensable
tool in the diagnosis, management and follow-up of patients with retinal
disorders. Forthcoming innovations in OCT technologies include volumetric
three-dimensional reconstruction of retinal structures, swept-source OCT,
longer wavelength imaging, adaptive optics OCT, polarization-sensitive
OCT, and OCT systems for surgical guidance as well as intraoperative use.
Translating these techniques from the laboratory to the clinic has already
begun.
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