Table of Contents - WOC 2012
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Age-Related Macular Degeneration: New Non-Surgical Treatment<br />

Sat 18 Feb 15:30 - 17:00 Hall 3<br />

IS-RET-SA 232 (1)<br />

Treatments for Geographic Atrophy<br />

Chew Emily (1)<br />

1. National Institutes <strong>of</strong> Health<br />

We have made tremendous advances in the treatment <strong>of</strong> wet age-related<br />

macular degeneration (AMD). Our new challenge is the treatment <strong>of</strong> dry<br />

AMD, the most vision-threatening form <strong>of</strong> which is geographic atrophy (GA).<br />

Current clinical research in GA treatment is directed to preservation <strong>of</strong> the<br />

photoreceptors and retinal pigment epithelium (RPE); prevention <strong>of</strong> oxidative<br />

damage; and suppression <strong>of</strong> inflammation. Course attendees will learn the<br />

different mechanisms and effects <strong>of</strong> new and investigational pharmacological<br />

agents and their potential clinical applications.<br />

IS-RET-SA 232 (2)<br />

The Role <strong>of</strong> Reticular Drusen in AMD<br />

Chew Emily (1)<br />

1. National Institutes <strong>of</strong> Health<br />

Reticular drusen, yellowish white interlacing lesions seen around the retinal<br />

vasculature, is a subtype <strong>of</strong> age-related macular degeneration (AMD) best<br />

detected with fundus aut<strong>of</strong>luorescence imaging or infrared imaging. Reticular<br />

drusen was associated with an increased risk <strong>of</strong> developing advanced AMD,<br />

especially in women, in some case series while reticular drusen was also<br />

present in eyes without drusen or signs <strong>of</strong> AMD. Genetic associations have<br />

been found with chromosome 10. The clinical significance <strong>of</strong> reticular drusen<br />

is yet to be determined.<br />

IS-RET-SA 232 (3)<br />

What Do We Have to Modify in the Management <strong>of</strong> Exudative AMD,<br />

After CATT Study Results<br />

Coscas Gabriel (1)<br />

1. University Paris XII. Hospital Creteil, Department <strong>of</strong> Ophthalmology<br />

The results <strong>of</strong> CATT study are already known: non-inferiority <strong>of</strong> Bevacizumab<br />

and no statistically differences in systemic safety have been shown. Retinal<br />

specialists can choose the authorized treatment. Patients with cardiovascular<br />

or hemorrhagic disease should be referred for a systemic work-up. There is<br />

a consensus for a monthly follow-up, with visual acuity, biomicroscopy and<br />

Optical Coherence Tomography (OCT); fluorescein and Indocyanine green<br />

angiography if required. Spectral Domain OCT could differentiate between<br />

signs <strong>of</strong> activity and degenerative changes (tubulation, retinal pseudo cysts).<br />

IS-RET-SA 232 (4)<br />

How OCT can Best be Used to Evaluate New Treatments<br />

Sadda SriniVas (1)<br />

1. University <strong>of</strong> Southern California, Doheny Eye Institute<br />

Optical coherence tomography (OCT) has dramatically altered the practice <strong>of</strong><br />

retina providing unprecedented morphologic information as well as objective,<br />

automated, quantitative data which can be used to monitor response to therapy.<br />

However, this data, typically in the form <strong>of</strong> retinal thickness measurements,<br />

may be erroneous in certain situations and represents only a small fraction<br />

<strong>of</strong> the potential data available in OCT images. More detailed analysis and<br />

quantification <strong>of</strong> substructures on OCT can provide an improved understanding<br />

<strong>of</strong> the effects <strong>of</strong> therapies.<br />

IS-RET-SA 232 (5)<br />

Anti-VEGF Therapy in AMD: Substances and Strategies<br />

Schmidt-Erfurth Ursula (1)<br />

1. Medical University <strong>of</strong> Vienna<br />

Background: Intensive efforts are ongoing to optimize treatment outcomes and<br />

management. Methods: Ranibizumab (Lucentis) is approved, VEGFtrap<br />

(Eyelea) is submitted for approval, Bevacizumab (Avastin) is in <strong>of</strong>f-labeluse.<br />

Results: Ranibizumab is the first line recommendation. Recent<br />

findings (CATT-study) suggest a monthly treatment schedule or monthly<br />

controls together with a PRN-regimen. Bevacizumab achieves similar results<br />

only in a strict monthly retreatment regimen. VEGF-trap will <strong>of</strong>fer a fixed<br />

bimonthly schedule. Conclusion: Ranibizumab, Bevacizumab and VEGF-trap<br />

are excellent options for treatment with different schedules.<br />

<strong>WOC</strong><strong>2012</strong> Abstract Book<br />

IS-RET-SA 232 (6)<br />

AMD: Its Potential Health and Economic Impact Around the World<br />

Braunstein Robert (1)<br />

1. Columbia University<br />

The geometric progression <strong>of</strong> new patients with Age Related Macular<br />

Degeneration has become an economic burden throughout the world. This<br />

presentation will compare the costs <strong>of</strong> treatment and social services in<br />

assessing the economic impact <strong>of</strong> treating these patients in various parts <strong>of</strong><br />

the world.<br />

Fillers, Grafts and Implants<br />

Sat 18 Feb 15:30 - 17:00 Hall 9<br />

IS-OCP-SA 233 (1)<br />

Eyelid Spacers - How Useful Are They?<br />

Sigurdsson Haraldur (1)<br />

1. Department <strong>of</strong> Ophthalmology, Landspitalinn, University <strong>of</strong> Iceland<br />

Eyelid spacers are useful in eyelid surgery either as an add-on to the tarsal<br />

plate or as a replacement, when the tarsal plate has to be removed. The<br />

material used can be autogen, homologous and autologous. The main focus<br />

will be on the authors experience with Permacol. The clinical conditions where<br />

spacers are useful will be demonstrated.<br />

IS-OCP-SA 233 (2)<br />

Eyelid Spacers - Longterm Results and Complications<br />

Strianese Diego (1)<br />

1. University <strong>of</strong> Naples ‹Federico II›<br />

Eyelid retraction occurs commonly in Graves ophthalmopathy and facial palsy,<br />

secondary to surgery, trauma or cicatrisation, or in post-enucleation socket<br />

syndrome (PESS). It is challenging to correct, and requires use <strong>of</strong> a spacer<br />

to support the eyelid. All spacers have potential disadvantages: sclera carries<br />

a risk <strong>of</strong> transmissible encephalopathies, Medpore has risk <strong>of</strong> exposure<br />

while autogenous grafts have potential donor site morbidity plus time and<br />

anaesthetic considerations. Materials such as Mersilene mesh are not rigid<br />

enough to provide much support.<br />

IS-OCP-SA 233 (3)<br />

Fillers for the Periorbital Rejuvenation - Types <strong>of</strong> Fillers and<br />

Complications<br />

Malet Thierry<br />

Abstract not available<br />

IS-OCP-SA 233 (4)<br />

Orbital Implants in the Management <strong>of</strong> Congenital Clinical<br />

Anophthalmus - New Developments<br />

Guth<strong>of</strong>f Rudolf F. (1)<br />

1. University <strong>of</strong> Rostock, Eye Department<br />

In congenital clinical anophthalmus orbital volume augmentation is an<br />

important issue to optimize patients’ satisfaction. In bilateral and unilateral<br />

congenital clinical anophthalmus self-inflating conjunctival socket and orbital<br />

tissue expanders have shown to achieve very satisfactory results and reduce<br />

the number <strong>of</strong> surgical procedures required. Close cooperation with ocularists<br />

is mandatory. Own experiences in the treatment <strong>of</strong> congenital anophthalmus<br />

and the special use <strong>of</strong> self-inflating osmoexpanders in more than 100 children<br />

are presented.<br />

229

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