Table of Contents - WOC 2012

WOC2012 Abstract Book
Ocular Lymphoma
Sat 18 Feb 13:30 - 15:00 Conference Room A2
IS-ONC-SA 212 (1)
Ocular Adnexal Lymphomas: Overview on Ocular Adnexal
Lymphomas
Heegaard Steffen (1)
1. University of Copenhagen
Lymphoma of the ocular region is relatively uncommon, accounting for 5%-
10% of all extranodal lymphomas. It is, however, the most common orbital
malignancy. An overview of lymphoma of the ocular adnexal region consisting
of the orbit, conjunctiva, lacrimal gland and lacrimal sac will be presented. The
different subtypes will be introduced and treatment strategies and survival data
will be given. This is important since the subtypes behave differently regarding
relapse and survival and different treatment strategies should be considered.
IS-ONC-SA 212 (2)
Ocular Adnexal Lymphomas: Update on the Pathogenesis of Ocular
Adnexal MALT Lymphoma
White Valerie (1)
1. University of British Columbia
I will review the known mechanisms of pathogenesis of extranodal marginal
zone lymphomas of MALT type involving the ocular adnexa. These lymphomas
are thought to arise in a background of chronic antigenic, possibly infectious,
stimulation and are characterized by translocation-positive and translocationnegative
cytogenetic findings. Both of these pathways lead to secondary
genetic abnormalities involving deletions of A20 on chromosome 6q and gains
in TNF on 6p. Their disruption is postulated to lead to constitutive activation of
NF-kB and subsequent lymphomagenesis.
IS-ONC-SA 212 (3)
Ocular Adnexal Lymphomas: The Indian Experience of Ocular
Adnexal Lymphomas
Kashyap Seema (1)
1. All India Institute of Medical Sciences
Ocular adnexal Non Hodgkins Lymphoma were reviewed over a ten year
period in a major referral eye centre in northern India. We found male
predominance in our study. Majority of our cases were orbital NHL (64%)
followed by eyelid NHL (29%) and 6.45% of conjunctival NHL. Most of
these were B-cell extramarginal zone lymphomas. This session will give an
opportunity to delegates to enhance their knowledge, increase their awareness,
and share their experiences and knowledge at WOC 2012 with colleagues.
IS-ONC-SA 212 (4)
Ocular Adnexal Lymphomas: Unusual Eyelid Lymphomas
Tsuji Hideki (1)
1. The Cancer Institute Hospital
The importance of malignant lymphomas (ML) in ocular oncology is widely
known and most of them are mucosa associated lymphoid tissue (MALT)
lymphomas. Eyelid lymphomas constitute a small fraction of ocular adnexal
lymphomas (OAL), however, they have varieties of subtypes and sometimes
more aggressive coarse than that of other OAL especially MALT lymphomas.
“Unusual eyelid lymphomas” suggest to us about clinical and pathological
varieties of ML, and each subtype ML requires each prompt therapeutic
strategies.
IS-ONC-SA 212 (5)
Ocular Adnexal Lymphomas: Overview of Periocular and Ocular
Adnexal Lymphoproliferative Disorders in the Saudi Population
Alkatan Hind (1)
1. King Khaled Eye Specialist Hospital
Lymphoproliferative disorders represent a group with a basic unifying
histopathologic substrate of a densely cellular infiltrate mostly of small
lymphocytes. Their commonest presentation in the ophthalmic practice
is insidious painless orbital masses. An overall review of different
lymphoproliferative disorders affecting the orbit, eyelids and the lacrimal gland
which are encountered through tissue diagnosis at King Khaled Eye Specialist
Hospital over the last 11 years is presented. This information is useful to
general ophthalmologists as a baseline data for future studies.
214
IS-ONC-SA 212 (6)
Intraocular Lymphomas: Overview of Intraocular Lymphoma
Coupland Sarah (1)
1. University of Liverpool
Background and Purpose: Intraocular lymphomas are a heterogeneous group
of tumours, which demonstrate differing clinical courses and treatment
responses. The most common intraocular lymphoma is ‹vitreoretinal lymphoma›,
which is a high-grade B-cell Non Hodgkin›s lymphoma (NHL), often
associated with cerebral disease. The aims of this presentation are to discuss
the different types of intraocular lymphomas, how they differ from each other
clinically, morphologically, immunophenotypically and genotypically.
Methods and Results: The WHO lymphoma classification (2008) will be briefly
reviewed. This will be followed by an overview of terminology applied to
vitreoretinal lymphoma and what could be considered most appropriate. The
morphological, immunophenotypic and genotypic features of vitreoretinal
lymphoma will then be summarised. Vitreoretinal lymphoma differs significantly
from its other intraocular counterparts, e.g. primary choroidal lymphoma, which
is usually a low-grade B-cell lymphoma similar to the ‹MALT› lymphomas of
the ocular adnexa and with no involvement of the CNS. Secondary choroidal
lymphomas represent an ocular manifestation of systemic NHL. Treatment of
intraocular lymphoma is dependent on its location and WHO subtyping.
Conclusions: It is important to be more precise with the terminology of
intraocular lymphomas as they are heterogeneous malignancies with differing
clinical courses and treatment responses. Only through understanding their
development will it be possible to design more effective therapies.
IS-ONC-SA 212 (7)
Intraocular Lymphomas: Typical Presentations of Vitreoretinal
Lymphoma
Davis Janet (1)
1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
The objective of this presentation is to illustrate the clinical features of
vitreoretinal lymphoma in order to enhance the clinician›s ability to identify
cases of intermediate and posterior uveitis that may benefit from diagnostic
vitrectomy. Features discussed include clinical symptoms, characteristic
features of the vitreous infiltrate, and the vascular, retinal and RPE
manifestations of lymphoma. Typical findings of angiography and OCT will be
presented.
IS-ONC-SA 212 (8)
Intraocular Lymphomas: Atypical Presentations of Vitreoretinal
Lymphoma
Bodaghi Bahram (1)
1. Department of Ophthalmology, Pitie Hospital
Abstract not available
IS-ONC-SA 212 (9)
Intraocular Lymphomas: Treatment of Ocular Lymphomas
Al Kofide Amani (1)
1. King Faisal Specialist Hospital and Research Center
Ocular lymphomas constitute intraocular, orbital and adnexal lymphomas with
differing treatment approaches. Management depends on several factors
including location of tumor, age of patient, systemic and/or central nervous
system involvement, stage of tumor, whether or not it is primary or secondary
and hisotopathological classification. Current treatment for ocular lymphomas
will be discussed highlighting the multimodality approach including indications
for radiation therapy, surgery, adjuvant intraocular therapy, systemic and
intrathecal chemotherapy, immunotherapy and role of stem cell transplant.