Table of Contents - WOC 2012

WOC2012 Abstract Book
Pediatric Ophthalmology, Genetics
PO-PED-01
Apropose two cases of coloboma of the eyelid in the oculo-frontocutaneous
syndrome
Le Do Thuy Lan (1)
1. University of Medicine Pham Ngoc Thach
Objectives: Coloboma of the eyelid is able to associate with choristoma,
especially in syndromes about complexe anomalies. The authors analyzed two
cases which were identified in the new syndrome to understand clearly about
the pathology of coloboma of the eyelid.
Methods: Two cases of coloboma of the eyelid, one boy and one girl, the age
of 8 and 9, are living in Tay Nguyen and South Vietnam. Both cases were
examined systematically and performed paraclinic tests.
Results: Both cases had manifestations:coloboma of the upper eyelid,
choristoma on the cornea and conjunctiva, incomplete alopecia, cutaneous
nevoid lesions. Besides, one case had microphthalmia. The findings of
the syndrome involved disturbances of development of the embryo and
differentiated process of cranio-facial mass, they mixed embryonic dysgenesis
syndrome which were classified as the First Branchial Arch Anomalies.
Conclusions: Coloboma of the eyelid combined with choristoma may encounter
not only in the oculo-fronto-cutaneous syndrome which described by the
author Nguyen Duy Tan in 1973, but also in the clinical formes of coloboma of
the eyelid associated with systematic disorders.
PO-PED-02
No suture lensectomy in the pediatric population
O› Halloran Henry (1) , Fikhman Michael (1)
1. Rady Children›s Hospital
Objective; To look at the use of no suture Lensectomy in the pediatric
population. Methods; a retrospective of 10 years of no suture lensectomy in
our pediatric Patient Population. Results; We find the no suture teqhnique to
se safe and effective in children. Conclusion; we recommend the use of the no
suture technique in pediatric patients.
PO-PED-03
Surgery as primary intervention in glaucoma in the pediatric
population
O› Halloran Henry (1) , Fikhman Michael (1)
1. Rady Children›s Hospital
Objective; To determine if surgery is the best primary intervention for children
with glaucoma methods; a chart review of our pediatric glaucoma patients
over the past 5 years who were treated primarily either medically or surgically.
results; we found surgery to be a safe and effective primary treatment choice.
Conclusion; we recommend consideration of surgery rather than topical
medications as a primary treatment in the pediatric glaucoma population.
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PO-PED-04
Comparative study of bilateral lateral rectus recession versus OU
medial rectus tucking or OU medial rectus resection in the treatment
of intermittent exotropia
diab mohamed (1)
1. Pediatric and Strabismus
Purpose: To compare between bilateral lateral rectus recession versus OU
medial rectus tucking OU medial rectus resection in the treatment of intermittent
exotropia as regards surgical outcome in different age group and degree of
the strabismus Patients and methods 63 cases of intermittent exotropia were
divided into three equal surgical groups. Group A included cases whom bilateral
lateral rectus recession was done. Group B included cases in which bilateral
medial rectus tucking was done Group C included cases whom bilateral medial
rectus resection was proceeded
Results: When comparing the success rates of group A, B and C as regard the
grade of deviation measured pre operatively we can decide bilateral medial
rectus recession or tucking were more effective in larger angle of deviation.
As regard age group we can decide bilateral medial rectus recession or
tucking were more effective in older age group but can induce overcorrection
in younger age group
Conclusion: medial rectus recession or tucking is more safe and effective
procedure in the treatment of intermittent exotropia especially among large
angles of deviation in older patients
PO-PED-05
Association of Complement Factor H and ARMS2 Genotypes with
subtypes of Polypoidal Choroidal Vasculopathy
Tanaka Koji (1) , Nakayama Tomohiro (1) , Yuzawa Mitsuko (1)
1. Division of Ophthalmology Surugadai-Hospital Nihon University
Purpose: To clarify whether complement factor H (CFH) and age-related
maculopathy susceptibility 2 (ARMS2) genotypes are associated with subtypes
of polypoidal choroidal vasculopathy (PCV), such as polypoidal choroidal
neovascularization (CNV) and typical PCV.
Methods: We categorized 287 patients as having polypoidal CNV (85 patients)
or typical PCV (202 patients) based on indocyanine green angiographic
findings. 277 subjects without age-related macular degeneration (AMD) served
as controls. I62V (rs800292) in the CFH gene and A69S (rs10490924) in the
ARMS2 gene were genotyped, and case-control studies were performed in
subjects with these PCV subtypes.
Results: There were significant differences in all distributions of rs800292
between the case groups and the controls. Though there were significant
differences in all distributions of rs10490924 between the polypoidal CNV and
control groups, there was no difference between the typical PCV and control
groups. Logistic regression analysis with adjustment for confounding factors
showed the distributions of rs10490924 to differ highly significantly between
the controls and polypoidal CNV cases (p=2.1~10-10).
Conclusions: PCV might be genetically divided into polypoidal CNV and typical
PCV. The rs10490924 variant of the ARMS2 gene was shown to be associated
with polypoidal CNV. Typical PCV was not associated with this variant.