Table of Contents - WOC 2012

WOC2012 Abstract Book
PO-COR-2
Schnyder Corneal Dystrophy in a Saudi Arabian Family with
Heterozygous UBIAD1 Mutation (p.L121F)
AlGhadeer Huda (1) , Mohammed Jawahir (1) , Khan Arif (1)
1. King Khaled Eye Specialist Hospital
2. King Faisal Specialist Hospital
3. King Khaled Eye Specialist Hospital
Schnyder corneal dystrophy is a rare dominant disorder mostly reported in
Western and occasionally Asian populations. This report documents the
condition in an affected family from the historically isolated Arabian Peninsula.
A child and her mother had central crystalline keratopathy consistent
with Schnyder corneal dystrophy. Diagnostic UB1AD1 testing revealed a
known point mutation (c.361C>T, p.L121F) in both individuals. Available
asymptomatic family members had normal ophthalmic examinations and did
not have the mutation. Blood lipid profiles for the two patients revealed mildly
elevated total cholesterol and low-density lipoproteins. This report documents
Schnyder corneal dystrophy on the Arabian Peninsula and further confirms its
relationship with heterozygous UB1AD1 missense mutation.
PO-COR-3
Bilaterally Keratoconus in a Child with Bilaterally Nasolacrimal Duct
Stenosis: A Case Report
Zare Mohammad Ali (1)
1. Tehran University of Medical Sciences, Farabi eye Hosptal
Background: keratoconus is a disorder, which characterized with central
thinning of cornea that leads to irregular myopic astigmatism and reduction of
visual acuity.
Case presentation: A 14-year old boy that referred to our center with reduced
visual acuity and history of bilaterally nasolacrimal ducts stenosis and continual
epiphora, which result in long time eye rubbing. The diagnosis of bilateral
keratoconus was suggested in our patient by clinical findings (such as scissor
reflex, Munson sign and irregular astigmatism) and was confirmed by findings
of orb-scan topography.
Conclusion: We described the patients with bilateral nasolacrimal duct stenosis
and bilaterally keratoconus. In our case, ‹no organic cause was found to
explain the onset of keratoconus ‹other than persistent eye-rubbing due
to NLD obstruction in both eyes. The eye rubbing maybe suggested as a
possible etiology of keratoconus and nasolacrimal duct stenosis could be as
an associated condition with keratoconus as a congenital ocular anomaly.
Key Words: keratoconus, nasolacrimal duct stenosis, eye rubbing.
PO-COR-4
Clinicopathological Analysis of Repeat Descemet›s Stripping
Endothelial Keratoplasty or Penetrating Keratoplasty for Failed
Descemet›s Stripping Endothelial Keratoplasty
Ashar Jatin (1) , Pahuja Shivani (1) , Ramappa Muralidhar (1) , Chaurasia Sunita
(1) (1)
, Vaddavalli Pravin
1. L V Prasad Eye Institute
Purpose: To evaluate outcome of repeat (re) DSEK/penetrating keratoplasty
(PK) after DSEK and histology of failed DSEK.
Method: Retrospective analysis of reDSEK/ PK for failed DSEK from January
2006-June 2010.
Result: 18 eyes / 17 patients underwent DSEK for endothelial dysfunction.
Grafts failed in median 85(1-622) days. Re DSEK was performed in 14 while
4 had PK after 136.5 (13-622) days. Air through venting incisions helped to
detach lenticule. Follow up was 1 week to 16 months. Vision was