Table of Contents - WOC 2012

FP-OCP-TH 25 (9)
Bilateral Ritual Enucleation: A Case Report
Amos Silas (1) , Johnson Akang (1) , Helen Alen (1) , Thelma Ndife (1)
1. National Eye Centre
Aim: To highlight this rare cause of blindness particularly when the victim is
young and on the street without parental guidance at a very vulnerable and
impressionable age. We report a case of a 10 year old street urchin ‹Almajiri›
who was lured and had his two eyes forcefully enucleated for ritual purposes.
He sustained laceration of the upper lids; only remnants of orbital tissues were
seen bilaterally. He had surgery, redundant orbital tissues were excised, lids
repaired and a conformer was placed in the left socket. Patient is currently
undergoing rehabilitation.
Conclusion: The need to be our brothers’ keeper need not be overemphasized
in this situation, in as much as we do agree that there is need on the part of the
Government for legislation to protect our children as long as we still have street
urchins with us. We know that circumstances that throw them on to the streets
are beyond what the government alone can handle.
FP-OCP-TH 25 (10)
Life Expectancy Following Orbital Exenteration - A 13 Year
Manchester Review
Wong James (1) , Reshma Thampy (1) , Slater Roger (2) , Leatherbarrow Brian (1) ,
Cook Anne (1)
1. Manchester Royal Eye Hospital
2. Manchester Royal Infirmary
Introduction: Orbital exenteration is debilitating for a patient, both cosmetically
and psychologically. It requires a sensitive multidisciplinary team approach,
both preoperatively and postoperatively. We feel that providing life expectancy
information for patients during preoperative counseling is helpful.
Methods: A review was undertaken of an historical cohort of patients
exenterated for orbital malignancy from 1998 to 2010. The cases were
identified using an ICD-10 clinical code derived database and analyzed using
statistical software, Prism Ver5.04.
Results: 31 males and 42 females were identified. The mean age was 72 with
47 cases alive and 26 deceased. Our study demonstrates the HIGHEST ever
reported 5 years survival rate, 64%. Kaplan-Meier analysis for Basal Cell
Carcinoma (BCC) against non-BCCs gives a p value of 0.0199 with a hazard
ratio of 0.3927(CI: 0.1788 - 0.8626). Surprisingly, kaplan-meier analysis for
cleared against non-cleared margin gives a p value of 0.2890 with a hazard
ratio of 0.6571(CI: 0.3024-1.428).
Conclusion: Overall prognosis for patients who undergo orbital exenteration for
malignancy remains poor. We hypothesise that the causes are multi-factorial.
We recommend the development of a comprehensive Enhanced Recovery
after Surgery (ERAS) orbital pathway to optimise outcomes for this vulnerable
group of patients.
WOC2012 Abstract Book
Free Paper: Cataract
Thu 16 Feb 13:00 - 14:30 Conference Room A3
FP-CAT-TH 26 (1)
Cellular Change and Cell Death Mechanism in Cultured Human Lens
Epithelial Cells Induced by Cadmium Chloride
Koh Jae Woong (1) , Yang Yoori (2)
1. Department of Ophthalmology, Chosun University College of Medicine
2. Myung Eye Clinic
Purpose: To investigate the cellular change and cell death mechanism in
cultured human lens epithelial cells induced by smoking.
Methods: Cultured lens epithelial cells were challenged with 200, 400, 600,
800, 1000 uM of Cadmium chloride(CdCl2, Catalog No. 202908, Sigma-
Aldrich Chemical Co, USA) for 2 hours, and then were exposed to UV(280-
320nm/ 1.2mv/cm2). The cell viability was evaluated using the microscope and
3-(4,5-dimethylthiazol -2-yl)-2,5-dipheny tetrazolium bromice (MTT) assay. The
gene and protein level of caspase-8 and P53 were measured after exposed to
CdCl2 (600 uM) for 2 hours by using RT PCR and western blot.
Results: Compared to untreated cell, the cell death increased after Cadmium
chloride exposure in microscopic finding. And MTT assay demonstrated that
the cell death was increased in proportional to the increased Cadmium chloride
concentration. The expression of caspase-8 and P53 level all increased after
UV exposure in RT PCR and western blot.
Conclusion: Smoking induced cytotoxicity and apoptosis in human lens
epithelial cells.
Key words: Smoking, apoptosis, human lens epithelial cells.
Financial Disclosure: The author has no financial interest in any material or
method mentioned.
FP-CAT-TH 26 (2)
Prevalence of Pseudoexfoliation Among Patients Scheduled
for Cataract Surgery in South Saudi Arabia, King Khaled Hospital
Najran Study
Gabr Ahmed (1 , 2) , Soliman Ahmed (1 , 3) , Shaaban Hisham (1) , Ibrahim Mohammad
(1) , El Najjar Bashir (1)
1. King Khaled Hospital
2. Tanta Eye Hospital
3. Faculty of Medicine, Baniswaif University
Purpose: To report the prevalence of pseudoexfoliation (PXF) and its
associations in patients scheduled for cataract surgery in Najran district in the
south of Saudi Arabia.
Method: A series of 853 consecutive patients scheduled for routine cataract
surgery were examined for presence of pseudoexfoliation, intraocular pressure
(IOP) and type of cataract.
Results: Pseudoexfoliation was found in 205 of patients (24.03%), of whom 98
patients (47.81%) were unilaterally and 107 patients (52.19%) were bilaterally
affected. The mean age for pseudoexfoliation group was 72.21+ 10.27 year.
Ocular hypertension and glaucoma (IOP > 21 mmHg) were reported in 49
patients (23.9%) of pseudoexfoliation group and in 25 patients (3.85%) without
pseudoexfoliation, P value