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RF-values could be observed. A high repeatability in the R F
-values was obtained
with relative standard deviation (RSD) values lower then 1.5% for standards and
1.7% for extracts. Optimization of the chromatographic method enabled an efficient
separation of pharmaceuticals.
Figure 1: Chromatograms of: a) standard pharmaceutical mixture and b)
extracted samples from spiked soil, 1-NOR, 2-OTC, 3-TMP, 4-SDIAZ,
5-SMETH, 6-PGP and 7-SGUA
Linearity, limit of detection (LOD), limit of quantification (LOQ), precision and recovery
were evaluated for quantitative purposes. The regression analysis was performed
and the resulting parameters are shown in Table 2. R 2 values of the pharmaceuticals
were higher than 0.99 thus confirming the linearity of the method.
Limits of detection (LOD) and quantification (LOQ) for each pharmaceutical in the
mixture were determined from signal-to-noise ratio by comparing measured signals
from the samples with known low concentrations of analyte with those of the blank
samples (Table 2).
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