european college of sport science

TREADMILL EXERCISE ENHANCES ABCA1 EXPRESSION IN RAT LIVER
SAFARZADEH, A., GHANBARI-NIAKI, A., EBRAHIMI, M., RAHBARIZADEH, F.
TARBIAT MODARES UNIVERSITY
PP-PH09 Physiology 9
ATP-binding cassette transporters (ABCs) belong to a large family of the mammalian transmembrane transporters that play a crucial role
in plasma HDL-C remodeling. The purpose of this study was to investigate the expression of ABCA1 in rat liver in response to treadmill
exercise. Ten adult Wistar male rats (300-322 g) were used for this purpose. Animals were divided into control (n = 5) and Training (n = 5)
groups. Training group was given exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60min/day, 5 days/week for 12
weeks. Rats were sacrificed 48h after the last session of exercise. A portion of the liver were excised, immediately cleaned, washed in
ice-cold saline, and frozen in liquid nitrogen for extraction of ABCA1 mRNA expression and ATP measurement. Plasma collected for
plasma lipids, lipoproteins, apolipoprotein A-1, LCAT, and pre β-HDL measurements. Liver ABCA1 mRNA expression was significantly
(P