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Annual Meeting Proceedings Part 1 - American Society of Clinical ...

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6044 General Poster Session (Board #1G), Mon, 1:15 PM-5:15 PM<br />

Unintended consequences <strong>of</strong> health information technology: Evidence<br />

from Veterans Affairs Colorectal Cancer Oncology Watch Intervention.<br />

Presenting Author: John Bian, South Carolina College <strong>of</strong> Pharmacy,<br />

Columbia, SC<br />

Background: Although health information technology (HIT) has been hypothesized<br />

to help achieve greater adherence to recommended clinical guidelines<br />

and increase use <strong>of</strong> preventive care, well-conducted empirical studies<br />

evaluating this hypothesis are lacking. This study evaluated the ongoing<br />

Colorectal Cancer (CRC) Oncology Watch intervention, a clinical reminder<br />

system, implemented in 8 Veterans Affairs (VA) hospitals in 2008 for<br />

improving CRC (1) screening adherence among average- or higher-risk<br />

veterans, and (2) surveillance. Methods: VA administrative data were used<br />

to construct 4 cross-sectional groups <strong>of</strong> average-risk age 50-64 veterans,<br />

one for each <strong>of</strong> 2006, 2007, 2009, and 2010. We applied a linear<br />

probability model with hospital fixed-effects for estimation, using a natural<br />

experiment in which the 8 hospitals served as the intervention and other<br />

121 hospitals as a control and with 2006-2007 designated as the<br />

pre-intervention period and 2009-2010 as the post-intervention period.<br />

Results: The sample included 4,352,082 veteran-years in 4 years. The<br />

proportions adherent to screening were 37.6%, 31.6%, 34.4%, and<br />

33.2% in the intervention in 2006, 2007, 2009, and 2010, respectively,<br />

and the corresponding proportions in the control were 31.0%, 30.3%,<br />

32.3%, and 30.9%. Regression analysis showed that among those eligible<br />

for screening, the intervention was associated with a 2.2-percentage-point<br />

decrease in likelihood <strong>of</strong> adherence (P-value�0.0001). Additional analyses<br />

showed that the intervention was associated with a 5.6-percentagepoint<br />

decrease in likelihood <strong>of</strong> screening by colonoscopy among the<br />

adherent, but with increased total colonoscopies (any indication) <strong>of</strong> 3.6 per<br />

100 veterans age 50-64. Conclusions: The intervention may have slightly<br />

reduced CRC screening rates for the studied population. This consequence<br />

may have been caused by an unintentional shift <strong>of</strong> limited VA colonoscopy<br />

capacity from average-risk screening to higher-risk screening and to CRC<br />

surveillance, or by physicians’ fatigue due to the large number <strong>of</strong> clinical<br />

reminders implemented in the VA.<br />

6046 General Poster Session (Board #2B), Mon, 1:15 PM-5:15 PM<br />

Association <strong>of</strong> increases in quality <strong>of</strong> care with the NCI Community Cancer<br />

Center Program (NCCCP) pilot. Presenting Author: Michael T. Halpern, RTI<br />

International, Washington, DC<br />

Background: The NCCCP pilot is an initiative designed to enhance research<br />

and improve cancer care at community hospitals. As part <strong>of</strong> a multi-method<br />

evaluation <strong>of</strong> this pilot, we assessed changes in quality <strong>of</strong> care among the<br />

16 pilot NCCCP hospitals over time (before vs. after program initiation) and<br />

in comparison to a group <strong>of</strong> 25 similar hospitals that did not participate in<br />

the NCCCP. Methods: We compared changes in 5 NQF-approved quality <strong>of</strong><br />

care measures (3 for breast cancer, 2 for colon cancer) from 2006/07<br />

(before NCCCP initiation) vs. 2008/09/10 (post-initiation) for NCCCP and<br />

comparison group hospitals. Data were collected from all study hospitals<br />

using the Commission on Cancer’s Rapid Quality Reporting System, which<br />

allowed near real-time tracking <strong>of</strong> quality <strong>of</strong> care process measures. Results:<br />

Analyses included 18,608 breast cancer and 7,031 colon cancer patients.<br />

Patient-level concordance rates for all 5 quality <strong>of</strong> care measures increased<br />

significantly among both NCCCP and comparison group hospitals. The<br />

change (from baseline to post-NCCCP) in quality <strong>of</strong> care among NCCCP<br />

hospitals was significantly greater than the change among comparison<br />

group hospitals for two measures: radiation therapy following breast<br />

conserving surgery (RT-BCS) and hormonal therapy for women with<br />

hormone receptor positive breast cancer (HT). For the RT-BCS measure,<br />

NCCCP patients from underserved populations also experienced significantly<br />

greater changes in concordance than did corresponding populations<br />

from comparison group hospitals. In multivariate regression analyses<br />

controlling for patient characteristics, the change for the HT measure<br />

among NCCCP hospitals was significantly greater than that among comparison<br />

group hospitals. Conclusions: While both NCCCP and comparison group<br />

hospitals showed improved quality <strong>of</strong> care, participation in the NCCCP was<br />

associated with significantly greater improvements for a subset <strong>of</strong> measures.<br />

Including a separate comparison hospital group was critical for<br />

assessing changes associated with NCCCP participation while controlling<br />

for broader U.S. trends in improved quality <strong>of</strong> care. Future work will<br />

examine how hospital networks may have facilitated improvements in<br />

quality <strong>of</strong> care.<br />

Health Services Research<br />

393s<br />

6045 General Poster Session (Board #2A), Mon, 1:15 PM-5:15 PM<br />

Osteoporosis screening among prostate cancer survivors treated with<br />

androgen deprivation therapy. Presenting Author: Alicia Katherine Morgans,<br />

Massachusetts General Hospital Cancer Center, Boston, MA<br />

Background: Androgen deprivation therapy (ADT), the standard systemic<br />

treatment for prostate cancer, has adverse effects including bone loss and<br />

fractures. Current national guidelines suggest that men receiving ADT<br />

undergo dual energy x-ray absorptiometry (DXA) before and during ADT to<br />

better characterize fracture risk. We assessed receipt <strong>of</strong> DXA testing in a<br />

population-based cohort <strong>of</strong> men treated continuously with ADT for at least<br />

1 year and identified factors associated with testing. Methods: Using<br />

Surveillance, Epidemiology, and End Results-Medicare data, we identified<br />

men aged �65 with local or regional prostate cancer diagnosed during<br />

2001-2007 and followed through 2009 who received at least 1 year <strong>of</strong><br />

continuous ADT. We identified receipt <strong>of</strong> DXA testing in the 18-month<br />

period beginning 6 months before the first dose <strong>of</strong> ADT. We used logistic<br />

regression to identify factors associated with DXA testing, including patient<br />

and tumor characteristics and the physicians with whom they had outpatient<br />

visits. Results: Among 28,960 men treated with ADT for �1 year,<br />

6.5% had at least one DXA scan from 6 months before the first dose <strong>of</strong> ADT<br />

through 1 year after. DXA testing increased over time, with men initiating<br />

ADT in 2007-2009 more likely to be tested than those treated in<br />

2001-2002 (10.0% vs. 3.4%, OR 2.29, 95% CI 1.83-2.85). Men aged<br />

�85 were less likely than men aged 66-69 to undergo testing (OR 0.76,<br />

95% CI 0.65-0.89). Black men were less likely than white men to undergo<br />

testing (OR 0.92, 95% CI 0.61-0.86), as were men living in areas with<br />

lower educational attainment (P�.001). Compared with men seeing a<br />

urologist but no medical oncologist or primary care provider (PCP), men<br />

seeing a medical oncologist and a urologist (OR 2.11, 95% CI 1.39-3.21)<br />

and those seeing a medical oncologist, urologist and PCP (OR 2.59, 95%<br />

CI 2.01-3.34) had higher odds <strong>of</strong> testing. Conclusions: Few men receiving<br />

ADT for prostate cancer undergo DXA testing, with particularly low rates <strong>of</strong><br />

testing among older men, black men, and those living in areas with low<br />

educational attainment. Visits with a medical oncologist were associated<br />

with increased odds <strong>of</strong> testing. Interventions are needed to increase bone<br />

density testing among men receiving long-term ADT.<br />

6047 General Poster Session (Board #2C), Mon, 1:15 PM-5:15 PM<br />

Geographic and network analysis <strong>of</strong> oncology trials: Portfolio assessment <strong>of</strong><br />

<strong>Clinical</strong>Trials.gov. Presenting Author: Steven Kunyuan Cheng, Oregon<br />

Health & Science University, Portland, OR<br />

Background: Increasing complexity and specificity <strong>of</strong> cancer trials (CT)<br />

necessitates collaboration across the CT network to optimize research<br />

efforts. The relationship among CT sites and networks provide unique<br />

insights into improving coordination and accrual. Methods: 5971 interventional<br />

CTs registered between 2007 and 2010 were aggregated by trial and<br />

location. CTs in the Aggregate Analysis dataset from <strong>Clinical</strong>Trials.gov<br />

(AACT) were identified using MeSH terms. The distribution <strong>of</strong> mid-phase<br />

(MP)(phase I/II,II) and late-phase (LP)(PII/III,PIII) CTs for the ten most<br />

represented cancer types by number <strong>of</strong> sites was assessed using network<br />

graph theory and geographic analysis comparing distribution <strong>of</strong> trials across<br />

metropolitan statistical areas. Results: 66,566 CT sites were identified<br />

across the sample, 59.6% were in the United States (MP: 50.2%; LP:<br />

42.9%). Geographical availability <strong>of</strong> CTs and local cancer incidence rates<br />

were highly correlated (0.797, p� 0.001) but varied depending upon<br />

disease type. Network density (the degree <strong>of</strong> dyadic interconnections<br />

between sites studying similar cancer types) showed overall that MP trials<br />

were less dense with sparser interconnections among sites than LP trials.<br />

Network density <strong>of</strong> LP trials was higher for cancer types that had poorer<br />

correlation between geographic distribution <strong>of</strong> incidence and enrolling sites<br />

(-0.777, p�0.008). MP trials did not show a similar trend. Conclusions:<br />

The relationship between the distribution <strong>of</strong> CT and site location can be<br />

envisaged through geographic and network analysis <strong>of</strong> CT registry data. LP<br />

high-density networks should strive to diversify trial locations to better meet<br />

regional incidence rates.<br />

Incidence and trials MP (mid-phase) LP (late-phase)<br />

Pearson Corr.<br />

(all p

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