Dermatologic Differential Diagnosis.pdf. - Famona Site

98 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
IPEX syndrome – X-linked; immune dysregulation,
polyendocrinopathy, enteropathy; mutation of FOXP3; nummular
dermatitis, urticaria, scaly psoriasiform plaques of trunk and
extrexities, penile rash, alopecia universalis, bullae AD
140:466–472, 2004
Job’s syndrome – neonatal vesicular rash; vesicles on face and
scalp Ped Derm 5:175–182, 1988
Kindler’s syndrome AD 140:939–944, 2004; BJD 135:503–504,
1996; Ped Derm 13:397–402, 1996; AD 132:1487–1490, 1996;
JAAD 6:263–265, 1982
Lipoid proteinosis – vesicular lesions early BJD 151:413–423,
2004; JID 120:345–350, 2003; BJD 148:180–182, 2003; Hum
Molec Genet 11:833–840, 2002; JAAD 39:149–171, 1998
Mendes da Costa syndrome (dystrophia bullosa, typus
maculatus) – X-linked recessive; tense intraepidermal
bullae, alopecia, coarse reticulated hyperpigmentation of
face and extremities with atrophy, mental retardation Acta DV
(Stockh) 18:265, 1937; intraepidermal blisters, microcephaly,
mental retardation, atrichia, short conical fingers JAAD
50:S65–69, 2004
NOMID syndrome
Pachyonychia congenita – palmar and plantar bullae JAAD
19:705–711, 1988
Peeling skin syndrome, fissured cheilitis, blistering of palms and
soles, and desmosomal abnormalities JAAD 34:379–385, 1996
Proteus syndrome – lymphangioma circumscriptum, port
wine stains, subcutaneous hemangiomas and lymphangiomas,
hemihypertrophy of the face, limbs, trunk; macrodactyly,
cerebriform hypertrophy of palmar and/or plantar surfaces,
macrocephaly; verrucous epidermal nevi, sebaceous nevi with
hyper- or hypopigmentation Am J Med Genet 27:99–117, 1987;
vascular nevi, soft subcutaneous masses; lipodystrophy, café au
lait macules, linear and whorled macular pigmentation
Pediatrics 76:984–989, 1985; Am J Med Genet 27:87–97, 1987;
Eur J Pediatr 140:5–12, 1983
Reed syndrome – bullae of fingers and soles; absence of
dermatoglyphics
Relapsing polychondritis – vesicular eruption Clin Exp
Rheumatol 20:89–91, 2002
Reticulate hyperpigmentation with alopecia, nail changes, and
growth retardation with or without blisters Schweiz Med
Wochenschr 100:228–233, 1970; Monatsschr Kinderheilkd
78:773–781, 1939
Richner–Hanhart syndrome (tyrosinemia type II) – bullae of
palms and soles; palmoplantar keratoderma
Rothmund–Thomson syndrome (poikiloderma congenitale) –
autosomal recessive; occasional blisters after sun exposure
Am J Med Genet 22:102:11–17, 2001; Ped Derm 18:210212,
2001; Ped Derm 16:59–61, 1999; Dermatol Clin 13:143–150,
1995; JAAD 27:75–762, 1992
Rowell’s syndrome – lupus erythematosus and erythema
multiforme-like syndrome – papules, annular targetoid lesions,
vesicles, bullae, necrosis, ulceration, oral ulcers; perniotic
lesions JAAD 21:374–377, 1989
Shulman’s syndrome – eosinophilic fasciitis with superficial
blistering JAAD 1:221–226, 1979; Ann Rheum Dis 36:354–359,
1977
Sweet’s syndrome – plaques with bullae JAAD 31:535–536,
1994; BJD 76:349–356, 1964; plaques with bullae with acute
hepatitis B infection BJD 143:914–916, 2000; classical
pseudovesicular border
Wells’ syndrome (eosinophilic cellulitis) – vesiculobullous
plaques AD 139:933–938, 2003; BJD 143:425–427, 2000;
BJD 140:127–130, 1999; AD 133:1579–1584, 1997; JAAD
33:857–64, 1995; JAAD 18:105–114, 1988; Trans S. Johns
Hosp Dermatol Soc 51:46–56, 1971
Xeroderma pigmentosum – acute sunburn, persistent erythema,
freckling – initially discrete, then fuse to irregular patches of
hyperpigmentation, dryness on sun-exposed areas; with time
telangiectasias and small angiomas, atophic white macules
develop; vesiculobullous lesions, superficial ulcers lead to
scarring, ectropion; multiple malignancies; photophobia,
conjunctivitis, ectropion, symblepharon, neurologic
abnormalities Adv Genet 43:71–102, 2001; Hum Mutat 14:9–22,
1999; Mol Med Today 5:86–94, 1999; Derm Surg 23:447–455,
1997; Dermatol Clin 13:169–209, 1995; Recent Results Cancer
Res 128:275–297, 1993; AD 123:241–250, 1987; Ann Intern
Med 80:221–248, 1974; XP variant AD 128:1233–1237, 1992
TOXINS
Arsenic – acute arsenic intoxication; initially morbilliform
eruption with development of vesicles, pustules on red
background; followed by generalized desquamation and
palmoplantar lamellar desquamation BJD 141:1106–1109, 1999
Mercury poisoning – skin-colored to slightly red papules or
papulovesicles of palms or soles JAAD 49:1109–1111, 2003
Methyl bromide AD 124:917–921, 1988
Mustard gas exposure AD 128:775–780, 1992; JAAD
32:765–766, 1995, JAAD 39:187–190, 1998
Self-defense sprays (orthochlorobenzylidene malononitrile) AD
129:913, 1993
TRAUMA
Amputation stump friction blisters Rook p.905, 1998, Sixth Edition
Burns – thermal, chemical (hydrofluoric acid) Cutis 59:306–308,
1997), ultraviolet, infrared; chemical burn – bullous pemphigoid
induced by chemical burn JAAD 38:337–340, 1998
Chilblains – vesicles, bullae, ischemic necrosis; calcification
Rook p.3021, 1998, Sixth Edition
Child abuse – bullae from burns JAAD 5:203–212, 1981
Cold weather immersion foot – acral bullae Derm Clinics
17:1–17, 1999
Coma bullae – facial bullae, linear bullae Cutis 69:265–268, 2002;
Am J Dermatopathol 15:208–216, 1993; Cutis 45:423–426, 1990
Cryotherapy
Electron beam therapy
Erythema ab igne Rook p.937, 1998, Sixth Edition
Fracture blisters JAAD 30:1033–1034, 1994
Friction blisters Rook p.893–894, 1998, Sixth Edition
Frostbite Cutis 63:21–23, 1999; Rook p.958–959, 1998,
Sixth Edition
Neonatal sucking blister – fingers, lips, forearms Pediatrics
32:1099–2001, 1963
Nerve injury, traumatic – surgical injury to lateral femoral
cutaneous nerve with bulla and subsequent ulceration of lateral
lower leg Dermatol Wochenschri 136:971–973, 1957
Pressure bullae
Pressure urticaria – bullous delayed pressure urticaria BJD
153:435–439, 2005
Pulling boat hands JAAD 12:649–655, 1985
Radiation dermatitis, acute Acta DV 49:64–71, 1969;
lymphangiomatous papules following radiation therapy
Histopathology 35:319–327, 1999; bulla of the legs with pruritic
eruption with eosinophilia AD 137:821–822, 2001; eosinophilic
polymorphic and pruritic eruption associated with radiotherapy
(EPPER) – bullae, red papules, pruritic AD 137:821–822, 2001
Subcutaneous emphysema of eyelids – bullae over medial
canthi Rook p.2988, 1998, Sixth Edition