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Dermatologic Differential Diagnosis.pdf. - Famona Site

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Congestive heart failure<br />

Overwhelming infection – meningococcemia, pneumococcal,<br />

rickettsial, viral, fungal, other<br />

Miscellaneous – carbon monoxide poisoning, fibrin thrombi,<br />

cold injury, crutch pressure arteritis<br />

Mitral stenosis with or without left atrial wall thrombus<br />

Embolization – cholesterol, infectious, tumor, thromboembolic<br />

Myocardial infarction<br />

Pulmonary embolus<br />

Vasospastic – ergotism, Raynaud’s<br />

Primary venous disease – venous gangrene<br />

Syphilitic aortic aneurysm eroding through the sternum Dur M<br />

Cardiothorac Surg 10:922–924, 1996<br />

Takayasu’s arteritis – cutaneous necrotizing vasculitis NEJM<br />

352:700–707, 2005; Dermatology 200:139–143, 2000<br />

Temporal arteritis (giant cell arteritis) Arthritis Rheum 42:1296,<br />

1999; with scalp necrosis BJD 120:843–846, 1989; gangrene of<br />

leg, tongue necrosis BJD 151:721–722, 2004; BJD 76:299–308,<br />

1964<br />

Thromboangiitis obliterans (Buerger’s disease) Rook p.2233,<br />

1998, Sixth Edition; Am J Med Sci 136:567–580, 1908<br />

Thromboembolic phenomena – fingertip necrosis; cardiac source,<br />

arterial source, aneurysm (subclavian or axillary arteries),<br />

infection, hypercoagulable state AD 138:1296–1298, 2002<br />

Thrombosis – penile gangrene Rook p.3194, 1998, Sixth Edition<br />

Thrombosis of large vessels<br />

Thrombotic thrombocytopenic purpura<br />

Urticarial vasculitis Clin Rev Allergy Immunol 23:201–216, 2002<br />

Vasculitis – large and/or small vessel – leukocytoclastic<br />

vasculitis NEJM 352:700–707, 2005; AD 134:309–315, 1998;<br />

Rook p.2178, 1998, Sixth Edition; urticarial vasculitis AD<br />

134:231–236, 1998<br />

Vasoconstriction<br />

Venous stasis ulceration (chronic venous insufficiency) – medial<br />

lower leg and medial malleolus NEJM 352:700–707, 2005;<br />

AD 133:1231–1234, 1997; Semin Dermatol 12:66–71, 1993;<br />

with subcutaneous calcification J Derm Surg Oncol<br />

16:450–452, 1990<br />

Venous limb gangrene (phlegmasia cerulea dolens) – during<br />

warfarin treatment of cancer-associated deep venous<br />

thrombosis; due to severe depletion of protein C and failure to<br />

reduce thrombin generation Ann Intern Med 135:589–593, 2001<br />

Congenital Volkmann ischemic contracture (neonatal<br />

compartment syndrome) – upper extremity circumferential<br />

contracture from wrist to elbow; necrosis, cyanosis, edema,<br />

eschar, bullae, purpura; irregular border with central white<br />

ischemic tissue with formation of bullae, edema, or spotted<br />

bluish color with necrosis, a reticulated eschar or whorled<br />

pattern with contracture of arm; differentiate from necrotizing<br />

fasciitis, congenital varicella, neonatal gangrene, aplasia cutis<br />

congenital, amniotic band syndrome, subcutaneous fat<br />

necrosis, epidermolysis bullosa BJD 150:357–363, 2004<br />

Wegener’s granulomatosis – cutaneous necrosis NEJM<br />

352:700–707, 2005; papulonecrotic lesions JAAD 48:311–340,<br />

2003; Cutis 64:183–186, 1999; JAAD 31:615–622, 1994;<br />

necrotic penile ulcers Clin Rheumatol 17:239–241, 1998;<br />

JAAD 31:605–612, 1994; AD 130:1311–1316, 1994; genital and<br />

perineal necrosis Am J Med 108:680–681, 2000<br />

ESCHARS<br />

African tick bite fever (Rickettsia africae) – hemorrhagic pustule,<br />

purpuric papules; transmitted by Amblyomma ticks – high fever,<br />

arthralgia, myalgia, fatigue, rash in 2–3 days, with eschar,<br />

maculopapules, vesicles, and pustules JAAD 48:S18–19, 2003<br />

NEVI: SYNDROMES ASSOCIATED WITH NEVI 361<br />

Anthrax<br />

Antiphospholipid antibody syndrome<br />

Aspergillosis<br />

Boutonneuse fever<br />

Brown recluse spider bite<br />

Calciphylaxis<br />

Capnocytophaga canimorsus sepsis – dog and cat bites;<br />

necrosis with eschar; cellulitis Cutis 60:95–97, 1997; JAAD<br />

33:1019–1029, 1995<br />

Coumadin necrosis<br />

Ecthyma<br />

Ecthyma gangrenosum<br />

Fusariosis<br />

Glanders<br />

Heparin necrosis<br />

Herpes simplex virus<br />

Milker’s nodule<br />

Mucormycosis<br />

Necrotizing fasciitis<br />

Orf<br />

Phagedenic ulcer<br />

Queensland tick typhus<br />

Rat bite fever<br />

Rickettsial pox<br />

Scrub typhus<br />

Siberian typhus<br />

Tularemia<br />

NEVI: SYNDROMES ASSOCIATED<br />

WITH NEVI<br />

JAAD 29:374–388, 1993<br />

CONGENITAL NEVI<br />

Epidermal nevus syndrome Ped Derm 6:316–320, 1989<br />

Limb hypoplasia J Pediatr 120:906–911, 1992<br />

Linear nevus sebaceus syndrome<br />

Malformations associated with congenital nevi – spinal cord,<br />

vascular, neurocutaneous melanosis<br />

Melanocytic nevi along Blaschko’s lines Acta DV 78:378–380,<br />

1998<br />

Mills syndrome – giant congenital nevus and chronic<br />

progressive ascending hemiparesis Ital J Neurol Sci<br />

13:259–263, 1992<br />

Multiple hamartoma syndrome with congenital melanocytic<br />

nevus, epidermal nevi, vascular malformations, aplasia cutis<br />

congenita of the scalp, cartilage hamartoma, lipodermoid<br />

fibroma of the conjunctiva, and intracranial malformation Ped<br />

Derm 3:219–225, 1986<br />

NAME/LAMB (Carney) syndrome Curr Prob Derm VII:143–198,<br />

1995<br />

Neurocutaneous melanosis JAAD 35:529–538,1996;<br />

JAAD 24:747–755. 1991<br />

Neurofibromatosis Type I Neurology 35 (suppl 1):194, 1985<br />

Nevi spili along Blaschko’s lines Acta DV 78:378–380, 1998

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